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抑制剂描述: 产品名称:PE859 产品别名:见爱必信官网 英文别名:PE859 靶点:Amyloid-β CAS:1402727-29-0 纯度:98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder) 描述: PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively. 溶解性:DMSO : 50 mg/mL (111.48 mM; Need ultrasonic) 体外研究: PE859 inhibits the heparin-induced aggregation of both 3RMBD and full length tau in a concentration-dependent manner. In each assay, the IC50 values calculated at the last measurement periods are 0.81 μM, and 2.23 μM, respectively. PE859 inhibits tau aggregation through formation of beta-sheet structure. 体内研究:PE859 inhibits the heparin-induced aggregation of both 3RMBD and full length tau in a concentration-dependent manner. In each assay, the IC50 values calculated at the last measurement periods are 0.81 μM, and 2.23 μM, respectively. PE859 inhibits tau aggregation through formation of beta-sheet structure.
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