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仪器信息网试剂标物生化试剂生物分子 Apilimod mesylate

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Apilimod mesylate

价格：￥ 1082

品牌：爱必信

供货周期：一周

货号：abs810258

规格：>98%

CAS：870087-36-8

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抑制剂描述：

产品名称：Apilimod mesylate

产品别名：见爱必信官网

英文别名：Apilimod mesylate

靶点：PIKfyve

CAS：870087-36-8

纯度：>98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：Apilimod(STA 5326) is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM.

溶解性：10 mM in DMSO

体外研究：

in vitro: STA-5326 not only inhibited IL-12, but it also potently inhibited IL-23 and total p40 products in various forms as monomer, homodimer, and heterodimerin IFN-γ/SAC–stimulated human PBMCs . STA-5326 inhibited IFN-γ production induced by either IFN-γ/SAC or SAC in human PBMCs, with an IC50 of approximately 20 nM, while the compound had no significant effect on the production when T cells were stimulated using anti-CD3 and anti-CD28 antibodies, suggesting that the T-cell–receptor–dependent production of IFN-γ that occurs independently of suppression of Th1 cells via inhibition of IL-12 is not directly inhibited by the compound .

体内研究：Patients with CD responded within 14 days of treatment with apilimod and, after 28 days, the drug significantly reduced the Crohn's disease activity index (CDAI). Apilimod is currently in phase II clinical trials for rheumatoid arthritis, common variable immunodeficiency and CD. From the data available to date, apilimod appears to be a promising treatment for CD, and the oral formulation of this compound provides an advantage for apilimod over injectable therapies . Oral administration of either 5 mg/kg or 20 mg/kg STA-5326 reduced the severity of EAU on day 14 and 18. In addition, mice treated with 20 mg/kg STA-5326 showed significantly decreased severity of EAU by histopathological analysis .

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs810258	Apilimod mesylate	5mg	1082.00	立即咨询
abs810258	Apilimod mesylate	10mg	1682.00	立即咨询
abs810258	Apilimod mesylate	50mg	5748.00	立即咨询
abs810258	Apilimod mesylate	100mg	8676.00	立即咨询

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