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仪器信息网试剂标物生化试剂生物分子 SU1498

仪信通第 2 年

爱必信(上海)生物科技有限公司

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SU1498

价格：￥ 998

品牌：爱必信

供货周期：一周

货号：abs819415

规格：≥98%

CAS：168835-82-3

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抑制剂描述：

产品名称：SU1498

产品别名：见爱必信官网

英文别名：SU1498

靶点：VEGFR

CAS：168835-82-3

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20℃

描述：

SU1498 is a selective inhibitor of the VEGFR2; inhibits Flk-1 with an IC50 of value of 700 nM.

溶解性：DMSO ：78 mg/mL (199.73 mM)
Ethanol ：78 mg/mL (199.73 mM)

体外研究：

SU1498 stimulates accumulation of phosphorylated ERKs in human umbilical vein endothelial cells and in human aortic endothelial cells in a manner that is dependent on the functioning of the upstream components of the MAPK pathway, B-Raf, and MEK kinases. The enhanced accumulation of phospho-ERKs is observed only in cells that have been stimulated with sphingosine 1-phosphate or protein growth factors; SU1498 by itself is ineffective. SU1498 blocks signal transduction from VEGFR2 in MS1 VEGF cells.In the presence of SU1498, levels of Ets-1 are decreased, suggesting that VEGF-VEGFR-2 interactions contributed to baseline levels of Ets-1 expression, and interruption of this autocrine interaction with SU1498 led to decreased expression of Ets-1. SU1498 treatment significantly impacts U87 cell proliferation and apoptosis. SU1498 induces a marked increase in lipids and a decrease in glycerophosphocholine. Accordingly, accumulation of lipid droplets is seen in the cytoplasm of SU1498-treated U87 cells.

体内研究：

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs819415	SU1498	5mg	998.00	立即咨询
abs819415	SU1498	25mg	3570.00	立即咨询

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生化试剂 SU1498由爱必信(上海)生物科技有限公司为您提供，如想了解更多关于生物分子 SU1498的报价、规格、厂家等信息，欢迎来电或留言咨询。除供应SU1498外，爱必信(上海)生物科技有限公司还可为您提供：

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