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仪器信息网试剂标物生化试剂生物分子 SUN11602

仪信通第 2 年

爱必信(上海)生物科技有限公司

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SUN11602

价格：￥ 3431

品牌：爱必信

供货周期：一周

货号：abs814411

规格：>98%

CAS：704869-38-5

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抑制剂描述：

产品名称：SUN11602

产品别名：见爱必信官网

英文别名：SUN11602

靶点：FGFR

CAS：704869-38-5

纯度：>98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

SUN11602 is a small synthetic compound that mimics the neuroprotective activities of bFGF and activates key molecules in the FGF receptor-1-mitogen-activated protein kinase/extracellular signal-regulated kinase-1/2 kinase (FGFR-1-MEK/ERK) signaling pathway.

溶解性：DMSO : ≥ 37 mg/mL (81.93 mM)

体外研究：

Physiological actions of SUN11602 mimic several phenomena of the neuroprotection that is induced by bFGF. SUN11602 plays a pivotal role in allowing primary cultured neurons to survive in adverse environments of glutamate toxicity and activating intracellular key molecules that are involved in the neuroprotective mechanisms. These actions are quite similar to those of bFGF. Such neuroprotective mechanisms are specific and distinctive to SUN11602 and bFGF and differs clearly from those of the other growth factors that are investigated. But unlike bFGF, SUN11602 can either directly or indirectly trigger the phosphorylation of the cytosolic domain of the FGFR without binding to the extracellular domain of the FGFR-1. SUN11602 demonstrates no cell proliferative activity of somatic cells, unlike bFGF. SUN11602 significantly affects neuronal survival in adverse conditions through a FGFR1-mitogen-activated protein kinase/extracellular signal-regulated kinase-1/2 kinase (FGFR-1–MEK/ERK) signaling pathway.

体内研究：In WT mice, SUN11602 and bFGF increase the levels of newly synthesized Calb in cerebrocortical neurons and suppress the glutamate-induced rise in intracellular Ca2+. This Ca2+-capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate. In contrast, Calb levels remain unchanged in Calb-/- mice after exposure to SUN11602 or bFGF, and due to a loss of function of the gene, these neurons are no longer resistant to toxic conditions of glutamate. Neuroprotective activities of SUN11602 and FGF-2 are due to exogenously induced hyperexpression of CalB in hippocampal neurons. The pharmacokinetic properties of SUN11602 appear to hold promise in terms of bioavailability (>65%) after oral administration in rodents (rats and mice) and dogs (beagles).

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs814411	SUN11602	50mg	3431.00	立即咨询
abs814411	SUN11602	100mg	5093.00	立即咨询
abs814411	SUN11602	10mg	1163.00	立即咨询
abs814411	SUN11602	5mg	722.00	立即咨询

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生化试剂 SUN11602由爱必信(上海)生物科技有限公司为您提供，如想了解更多关于生物分子 SUN11602的报价、规格、厂家等信息，欢迎来电或留言咨询。除供应SUN11602外，爱必信(上海)生物科技有限公司还可为您提供：

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