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仪器信息网试剂标物生化试剂生物分子 Bavachalcone

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爱必信(上海)生物科技有限公司

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Bavachalcone

价格：￥ 2268

品牌：爱必信

供货周期：一周

货号：abs821858

规格：98%

CAS：28448-85-3

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抑制剂描述：

产品名称：Bavachalcone

产品别名：见爱必信官网

英文别名：Bavachalcone

靶点：Others

CAS：28448-85-3

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：Bavachalcone is a major bioactive compounds isolated from Psoralea corylifolia L.; has been widely used as traditional Chinese medicine; antibiotic or anticancer agent.IC50 value:Target:Bavachalcone inhibited osteoclast formation from precursor cells with the IC(50) of approximately 1.5 microg ml(-1). The activation of MEK, ERK, and Akt by receptor activator of nuclear factor kappaB ligand (RANKL), the osteoclast differentiation factor, was prominently reduced in the presence of bavachalcone. The induction of c-Fos and NFATc1, key transcription factors for osteoclastogenesis, by RANKL was also suppressed by bavachalcone . Bavachalcone exhibited a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro . Bavachalcone had stronger inhibition on UGT1A1 and UGT1A7 than corylin which did not inhibit UGT1A1, UGT1A3, UGT1A7, UGT1A8, UGT1A10, and UGT2B4. Data fitting using Dixon and Lineweaver-Burk plots demonstrated the noncompetitive inhibition of bavachalcone against UGT1A1 and UGT1A7-mediated 4-MU glucuronidation reaction. The values of inhibition kinetic parameters (Ki) were 5.41 μ M and 4.51μ M for UGT1A1 and UGT1A7, respectively .

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体内研究：

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs821858	Bavachalcone	5mg	2268.00	立即咨询

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生化试剂 Bavachalcone由爱必信(上海)生物科技有限公司为您提供，如想了解更多关于生物分子 Bavachalcone的报价、规格、厂家等信息，欢迎来电或留言咨询。除供应Bavachalcone外，爱必信(上海)生物科技有限公司还可为您提供：

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