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仪器信息网试剂标物生化试剂生物分子 Phentolamine mesilate

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Phentolamine mesilate

价格：￥ 349

品牌：爱必信

供货周期：一周

货号：abs817138

规格：＞98%

CAS：65-28-1

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抑制剂描述：

产品名称：Phentolamine mesilate

产品别名：见爱必信官网

英文别名：Phentolamine mesilate

靶点：Adrenergic Receptor

CAS：65-28-1

纯度：＞98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Phentolamine mesylate is a nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.

溶解性：DMSO : 37.8 mg/mL (100 mM)
water : 37.8 mg/mL (100 mM)

体外研究：

Phentolamine mesylate displaces binding of the selective alpha 1 receptor antagonists HEAT and prazosin and the alpha 2 receptor antagonists rauwolscine and RX 821002 with relatively high affinity in corpus cavernosum membranes. Phentolamine mesylate causes concentration dependent relaxation in erectile tissue strips pre-contracted with adrenergic agonists phenylephrine, norepinephrine, oxymetazoline and UK 14,304, as well as with non-adrenergic contractile agents Endothelin and KCl. Phentolamine mesylate induces relaxation of corpus cavernosum erectile tissue by direct antagonism of alpha 1 and 2 adrenergic receptors and by indirect functional antagonism via a non-adrenergic, endothelium-mediated mechanism suggesting nitric oxide synthase activation. Phentolamine, an alpha-adrenergic antagonist, blocks the vasoconstriction associated with the epinephrine used in dental anesthetic formulations, thus enhancing the systemic absorption of the local anesthetic from the injection site.

体内研究：Phentolamine is a reversible competitive alpha-adrenergic antagonist with similar affinities for alphal and alpha2 receptors. Phentolamine mesylate causes vasodilatation and thus hypotension by decreasing peripheral vascular resistance. Phentolamine mesylate (30 and 100 nM) dose-dependently enhances electrical field stimulation-induced relaxation of the rabbit corpus cavernosum. Phentolamine relaxes rabbit corpus cavernosum independent of alpha-adrenergic receptor blockade. Phentolamine mesylate relaxes nonadrenergic noncholinergic neurons of the rabbit corpus cavernosum by activating NO synthase and is independent of alpha-adrenergic receptor blockade.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs817138	Phentolamine mesilate	50mg	349.00	立即咨询
abs817138	Phentolamine mesilate	100mg	397.00	立即咨询
abs817138	Phentolamine mesilate	200mg	715.00	立即咨询
abs817138	Phentolamine mesilate	500mg	1182.00	立即咨询

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