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仪器信息网试剂标物生化试剂生物分子 Exendin-4 Acetate

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Exendin-4 Acetate

价格：￥ 3024

品牌：爱必信

供货周期： 7天

货号：abs818569

CAS：914454-01-6

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抑制剂描述：

产品名称：Exendin-4 Acetate

产品别名：见爱必信官网

英文别名：Exendin-4 Acetate

靶点：Glucagon Receptor

CAS：914454-01-6

纯度：

外观：见爱必信官网

保存方法：

描述：Exendin-4 Acetate, a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM.

溶解性：10 mM in H₂O

体外研究：

In human umbilical vein endothelial cells, exendin-4 significantly increases NO production, endothelial NO synthase (eNOS) phosphorylation, and GTP cyclohydrolase 1 (GTPCH1) level in a dose-dependent manner. Exendin-4 shows cytotoxic effects to MCF-7 breast cancer cells with IC50 of 5 μM at 48 hour.

体内研究：Both low- and high-dose exendin-4 treatment in ob/ob mice improve serum ALT and reduce serum glucose, insulin levels and calculated HOMA scores compared with control. Exendin-4-treated ob/ob mice sustain a marked reduction in the net weight gain in the final 4 weeks of the study period. Animals treated with exendin-4 have more pancreatic acinar inflammation, more pyknotic nuclei and weigh significantly less than control rats. Exendin-4 treatment is associated with lower insulin and leptin levels as well as lower HOMA values in rats. Exenatide causes dose-dependent relaxation of rat thoracic aorta, which is evoked via the GLP-1 receptor and is mediated mainly by H2S but also by NO and CO.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs818569	Exendin-4 Acetate	5mg	0.00	立即咨询
abs818569	Exendin-4 Acetate	1mg	3024.00	立即咨询

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