供应商免费入驻

仪器信息网试剂标物生化试剂生物分子 ML221

仪信通第 2 年

爱必信(上海)生物科技有限公司

认证：工商信息已核实

厂商展位

找不到产品？留下需求帮您找

一键询价

ML221

价格：￥ 840

品牌：爱必信

供货周期：一周

货号：abs814586

规格：>98%

CAS：877636-42-5

一键咨询

获取电话

详细信息

详细信息

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

抑制剂描述：

产品名称：ML221

产品别名：见爱必信官网

英文别名：ML221

靶点：Apelin Receptor

CAS：877636-42-5

纯度：>98%

外观：见爱必信官网

保存方法：Store at -20°C

描述：

ML221 is a potent apelin receptor (APJ) functional antagonist in cell-based assays that is >37-fold selective over the closely related angiotensin II type 1 (AT1) receptor. The IC50 values of ML221 are 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively.

溶解性：DMSO ：9 mg/mL (23.36 mM)

体外研究：

In a PAMPA permeability assay, ML221 exhibits moderate permeability. ML221 displays moderate plasma and poor microsomal stability, as it is rapidly metabolized in both human and mouse liver homogenates (4.2% and 4.9% remaining at 60 min). It shows no toxicity (>50 μM) toward human hepatocytes. ML221 displays limited cross reactivity against a range of GPCRs. ML221 inhibits endothelial cell proliferation by blocking apelin-APJ signaling without affecting the expression of VEGF and VEGFR2.

体内研究：Intraperitoneal administration of ML221 inhibits pathological angiogenesis but enhances the recovery of normal vessels into the ischemic regions in the retina of the OIR model mice. A single application of ML221 alleviates mechanical allodynia and heat hyperalgesia 7 days following chronic constriction injury (CCI), in a dose?dependent manner. Intraspinal delivery of ML221, at the onset of and in fully?established neuropathic pain, persistently attenuates CCI?induced pain hypersensitivity, indicating that the apelin?APJ system is involved in initiating and maintaining pain. Intrathecal ML221 downregulates phosphorylated extracellular signal?related kinase (ERK) in the rat spinal cord dorsal horn, suggesting that the effect of apelin on neuropathic pain may be mediated via ERK signaling.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs814586	ML221	10mg	840.00	立即咨询
abs814586	ML221	50mg	3150.00	立即咨询

产品更多信息请进入爱必信网站咨询

生化试剂 ML221由爱必信(上海)生物科技有限公司为您提供，如想了解更多关于生物分子 ML221的报价、规格、厂家等信息，欢迎来电或留言咨询。除供应ML221外，爱必信(上海)生物科技有限公司还可为您提供：

推荐专场