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仪器信息网试剂标物生化试剂生物分子 Pregnenolone

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Pregnenolone

价格：￥ 630

品牌：爱必信

供货周期：一周

货号：abs816919

规格：＞98%

CAS：145-13-1

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抑制剂描述：

产品名称：Pregnenolone

产品别名：见爱必信官网

英文别名：Pregnenolone

靶点：AChR

CAS：145-13-1

纯度：＞98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.

溶解性：DMSO : 21 mg/mL (66.4 mM)
Ethanol : 21 mg/mL (66.4 mM)

体外研究：

Pregnenolone induces a large, dose-related increase of both the rate and extent of MAP2-induced tubulin assembly, whereas progesterone, inactive per se, counteracted the stimulatory effect of Pregnenolone. Pregnenolone-increased assembly of microtubules produces a completely normal structure. Pregnenolone preserves microtubule abundance and promotes cell movement during epiboly. Pregnenolone results in dramatic reduction in GR nuclear localization in mouse hippocampal cell line (HT-22). Pregnenolone has neuroprotective effects against both glutamate and amyloid beta protein neuropathology.

体内研究：Pregnenolone sustains its proliferative activity in vivo and stimulates the growth of LNCaP-tumor xenografts in intact male SCID mice as well as in castrated animals. Pregnenolone is shown to activate transcription through the LNCaP androgen receptor (AR), but not the wild-type AR. Pregnenolone results in a significant decrease in the accumulation of astrocytes in the proximity of the wound and in a decreased bromodeoxyuridine incorporation in reactive astrocytes of rats. Pregnenolone administration results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis and inflammation, modulates the hypothalamic-pituitary-adrenal axis, and markedly increases GABA(A) receptor responses. Pregnenolone administration elevates pregnenolone sulfate, a neurosteroid that positively modulates NMDA receptors.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs816919	Pregnenolone	100mg	630.00	立即咨询
abs816919	Pregnenolone	50mg	473.00	立即咨询
abs816919	Pregnenolone	200mg	788.00	立即咨询
abs816919	Pregnenolone	500mg	945.00	立即咨询

产品更多信息请进入爱必信网站咨询

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