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仪器信息网试剂标物生化试剂生物分子 Fasudil

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爱必信(上海)生物科技有限公司

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Fasudil

价格：￥ 1117

品牌：爱必信

供货周期：一周

货号：abs812829

规格：≥98%

CAS：103745-39-7

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抑制剂描述：

产品名称：Fasudil

产品别名：见爱必信官网

英文别名：Fasudil

靶点：ROCK

CAS：103745-39-7

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20°C

描述：

Fasudil hydrochloride (INN) is a potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which is often due to subarachnoid hemorrhage, as well as to improve the cognitive decline seen in stroke victims. It has been found to be effective for the treatment of pulmonary hypertension.

溶解性：10 mM in DMSO

体外研究：

Fasudil has vasodilatory action and occupies the adenine pocket of the ATP-binding site of the enzyme. Fasudil produces a competitive inhibition of the Ca2+-induced contraction of the depolarized rabbit aorta. Fasudil inhibits contractile responses to KCl, phenylephnne (PHE) and prostaglandin (PG) F2a. Fasudil also exhibits vasodilator actions by inhibition of 5-hydroxytryptamine, noradrenaline, histamine, angiotensin, and dopamine induced spiral strips contraction. In addition, Fasudil induces disorganization of actin stress fiber and cell migration inhibition. Fasudil inhibits hepatic stellate cells spreading, the formation of stress fibers, and expression of α-SMA with concomitant suppression of cell growth, but does not induce apoptosis. Fasudil also blocks the LPA-induced phosphorylation of ERK1/2, JNK and p38 MAPK.

体内研究：Fasudil (30 μg) increases CBF by 50% via intra-coronary injection to dogs. Fasudil (0.01, 0.03, 0.1 and 0.3 mg/kg, bolus, i.v.) decreases MBP and increases HR, VBF, CBF, RBF, and FBF. Fasudil (1.0 ng/mL) increases cardiac output. Fasudil via i.v. produces a significant fall in MBP, left ventricular systolic pressure and total peripheral resistance with an increase in HR and cardiac output, but without obvious effect on right atrial pressure, dP/dt or left ventricular minute work in dogs. Fasudil exhibits protectable effects on cardiovascular disease and reduces the activation of JNK and attenuates mitochondrial-nuclear translocation of AIF under ischemic injury. Fasudil (100 mg/kg/day, p.o.) significantly reduces incidence and mean maximum clinical score of EAE in SJL/J mice immunized with PLP p139-151. Fasudil inhibits the proliferative response of splenocytes to the antigen in mice. Fasudil decreases inflammation, demyelination, axonal loss and APP positivein spinal cord of Fasudil-treated mice via p.o. administration.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs812829	Fasudil	250mg	1117.00	立即咨询
abs812829	Fasudil	500mg	1446.00	立即咨询

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生化试剂 Fasudil由爱必信(上海)生物科技有限公司为您提供，如想了解更多关于生物分子 Fasudil的报价、规格、厂家等信息，欢迎来电或留言咨询。除供应Fasudil外，爱必信(上海)生物科技有限公司还可为您提供：

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