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仪器信息网试剂标物生化试剂生物分子 AG-221

仪信通第 2 年

爱必信(上海)生物科技有限公司

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AG-221

价格：￥ 889

品牌：爱必信

供货周期：一周

货号：abs810199

规格：>98%

CAS：1446502-11-9

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抑制剂描述：

产品名称：AG-221

产品别名：见爱必信官网

英文别名：AG-221

靶点：IDH

CAS：1446502-11-9

纯度：>98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：AG-221 is an orally available, selective, potent inhibitor of the mutated IDH2 protein.

溶解性：DMSO 100 mg/mL (211.24 mM)
Ethanol 100 mg/mL (211.24 mM)

体外研究：

Enasidenib (AG-221) reverses the effects of mutant IDH2 on DNA methylation in mutant stem/progenitor cells. Enasidenib induces differentiation and impairs self-renewal of IDH2-mutant leukemia cells, effects that are further enhanced by simultaneous inhibition of Flt3ITD. Enasidenib (AG-221) therapy induces differentiation of leukemic cells, with an increase in the CD11b+ population and a decrease in the c-Kit+ population in the peripheral blood at 2wks.

体内研究：Treatment with Enasidenib (AG-221) significantly improves survival in an IDH2-mutant acute myeloid leukemia (AML) primary xenograft mouse model. Enasidenib (AG-221), a mutant IDH2 inhibitor, remodels the epigenetic state of IDH2-mutant cells and induces alterations in self-renewal/differentiation in IDH2-mutant AML model in vivo. Enasidenib treatment (10mg/kg or 100mg/kg bid) leads to a reduction in 2-HG in vivo (96.7% below pre-treatment levels). Moreover, Enasidenib treatment restores megakaryocyte-erythroid progenitor (MEP) differentiation that is suppressed by mutant IDH2 expression (mean MEP% mean, 39% Veh vs 50% AG-221). Enasidenib therapy reverses the effects of mutant IDH2; a significant reduction is observed in DNA methylation, including 180 genes that have 20 or more hypomethylated differentially methylated cytosines (DMCs) following treatment. Enasidenib (100mg/kg bid) treatment of mice engrafted with Mx1-Cre IDH2R140QFlt3ITD AML cells markedly reduces 2-hydroxyglutarate (2-HG) levels consistent with on target inhibition. Enasidenib inhibits mutant IDH2-mediated 2-HG production.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs810199	AG-221	5mg	889.00	立即咨询
abs810199	AG-221	10mg	1508.00	立即咨询
abs810199	AG-221	50mg	5435.00	立即咨询
abs810199	AG-221	100mg	7889.00	立即咨询

产品更多信息请进入爱必信网站咨询

生化试剂 AG-221由爱必信(上海)生物科技有限公司为您提供，如想了解更多关于生物分子 AG-221的报价、规格、厂家等信息，欢迎来电或留言咨询。除供应AG-221外，爱必信(上海)生物科技有限公司还可为您提供：

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