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仪器信息网试剂标物生化试剂生物分子 Teriflunomide

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爱必信(上海)生物科技有限公司

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Teriflunomide

价格：￥ 630

品牌：爱必信

供货周期：一周

货号：abs812856

规格：>98%

CAS：108605-62-5

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抑制剂描述：

产品名称：Teriflunomide

产品别名：见爱必信官网

英文别名：Teriflunomide

靶点：Dehydrogenase

CAS：108605-62-5

纯度：>98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.

溶解性：DMSO：32mg/ml(118.43 mM)

体外研究：

Teriflunomide primarily acts as an inhibitor of dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme involved in the de novo synthesis of pyrimidines in rapidly proliferating cells. By reducing the activity of high-avidity proliferating T lymphocytes and B lymphocytes, teriflunomide likely attenuates the inflammatory response to autoantigens in MS. Thus, teriflunomide can be considered a cytostatic rather than a cytotoxic drug to leukocytes.

体内研究：Teriflunomide has demonstrated beneficial effects in two independent animal models of demyelinating disease. In the dark agouti rat model of experimental autoimmune encephalitis (EAE), teriflunomide administration results in clinical, histopathological, and electrophysiological evidence of efficacy both as a prophylactic and therapeutic agent. Similarly, in the female Lewis rat model of EAE, teriflunomide administration results in beneficial prophylactic and therapeutic clinical effects, with a delay in disease onset and symptom severity.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs812856	Teriflunomide	50mg	630.00	立即咨询
abs812856	Teriflunomide	100mg	1029.00	立即咨询

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生化试剂 Teriflunomide由爱必信(上海)生物科技有限公司为您提供，如想了解更多关于生物分子 Teriflunomide的报价、规格、厂家等信息，欢迎来电或留言咨询。除供应Teriflunomide外，爱必信(上海)生物科技有限公司还可为您提供：

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