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仪器信息网试剂标物生化试剂生物分子 5-Iodotubercidin

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5-Iodotubercidin

价格：￥ 920

品牌：爱必信

供货周期：一周

货号：abs816236

规格：99%

CAS：24386-93-4

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抑制剂描述：

产品名称：5-Iodotubercidin

产品别名：见爱必信官网

英文别名：5-Iodotubercidin

靶点：Adenosine Kinase

CAS：24386-93-4

纯度：99%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

5-Iodotubercidin is a potent <b>adenosine kinase</b> inhibitor with <b>IC50</b> of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.

溶解性：DMSO : 19.6 mg/mL (50 mM)

体外研究：

5-Iodotubercidin(Itu) is a genotoxic drug that activates the Atm-p53 pathway and has anti-tumor activity. Itu is unique compared to other nucleoside analogs in the way that it induces G2 arrest in a p53 -dependent manner. Moreover, at higher doses, Itu might activate p53-independent pathways, which may cooperate with p53 to kill cells and inhibit tumor growth. Incorporation of Itu metabolite into DNA causes DNA breaks, which triggers the DNA damage response. Itu might be a potential chemotherapeutic drug with distinct working mechanisms.

体内研究：5-Iodotubercidin is a potent inhibitor of adenosine kinase in the rat brain. 5-iodotubercidin has potent hypotensive, muscle relaxant, and hypothermic actions in mice, and that these effects could be blocked by theophylline, an adenosine receptor antagonist. 5-iodotubercidin (1 mg/kg, i.p.) administered prior to an ischemic episode, fails to provide a degree of cerebroprotection, assessed either by locomotor or histopathological indices Even though 5-iodotubercidin administration is known to enhance extracellular adenosine levels in brain slices.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs816236	5-Iodotubercidin	5mg	920.00	立即咨询
abs816236	5-Iodotubercidin	25mg	3417.00	立即咨询
abs816236	5-Iodotubercidin	10mg	1655.00	立即咨询

产品更多信息请进入爱必信网站咨询

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