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仪器信息网试剂标物生化试剂生物分子 Tubulin inhibitor 1

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Tubulin inhibitor 1

价格：￥ 4410

品牌：爱必信

供货周期：一周

货号：abs821709

CAS：2237054-53-2

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抑制剂描述：

产品名称：Tubulin inhibitor 1

产品别名：见爱必信官网

英文别名：Tubulin inhibitor 1

靶点：Microtubule/Tubulin;Apoptosis

CAS：2237054-53-2

纯度：

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：Tubulin inhibitor 1 is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis.

溶解性：

体外研究：

Tubulin inhibitor 1 (Compound 7a3) is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization.Tubulin inhibitor 1 has potent anti-proliferative activity against SK-OV-3, MDA-MB-231, HeLa, A549, CT26 and MCF-7 cells, with IC50s of 16.7 ± 3.0, 31.4 ± 0.7, 32.8 ± 2.9, 67.0 ± 0.8, 58.0 ± 2.4 and 35.4 ± 5.6 nM, respectively.Tubulin inhibitor 1 (40, 80, and 160 nM, 48 hours) markedly causes cellular mitotic arrest in the G2/M phase, induces apoptosis in SK-OV-3 cells.Apoptosis AnalysisCell Line:SK-OV-3 cellsConcentration:40, 80, and 160 nMIncubation Time:48 hResult:Induced apoptosis in SK-OV-3 cells after treatment for 48 h.

体内研究：Tubulin inhibitor 1 (Compound 7a3) is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization.Tubulin inhibitor 1 has potent anti-proliferative activity against SK-OV-3, MDA-MB-231, HeLa, A549, CT26 and MCF-7 cells, with IC50s of 16.7 ± 3.0, 31.4 ± 0.7, 32.8 ± 2.9, 67.0 ± 0.8, 58.0 ± 2.4 and 35.4 ± 5.6 nM, respectively.Tubulin inhibitor 1 (40, 80, and 160 nM, 48 hours) markedly causes cellular mitotic arrest in the G2/M phase, induces apoptosis in SK-OV-3 cells.Apoptosis AnalysisCell Line:SK-OV-3 cellsConcentration:40, 80, and 160 nMIncubation Time:48 hResult:Induced apoptosis in SK-OV-3 cells after treatment for 48 h.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs821709	Tubulin inhibitor 1	5mg	4410.00	立即咨询
abs821709	Tubulin inhibitor 1	50mg	20790.00	立即咨询

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