供应商免费入驻

仪器信息网试剂标物生化试剂生物分子 Nedaplatin

仪信通第 2 年

爱必信(上海)生物科技有限公司

认证：工商信息已核实

厂商展位

找不到产品？留下需求帮您找

一键询价

Nedaplatin

价格：￥ 527

品牌：爱必信

供货周期：一周

货号：abs817528

规格：99%

CAS：95734-82-0

一键咨询

获取电话

详细信息

详细信息

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

抑制剂描述：

产品名称：Nedaplatin

产品别名：见爱必信官网

英文别名：Nedaplatin

靶点：DNA Alkylator/Crosslinker

CAS：95734-82-0

纯度：99%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucleophilic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death.

溶解性：Water : 15 mg/mL (49.5 mM)

体外研究：

Nedaplatin (Aqupla) is a derivative of cisplatin for inhibition of tumor colony forming units with IC50 of 28.5 μg/mL. Nedaplatin is a platinum compound which is used for cancer chemotherapy. Nedaplatin inhibits the proliferation of SBC-3 cells by 98%, 93%, 75%, 54%, 27%, 6%, and 2% at a concentration of 0.005 μg/mL, 0.01 μg/mL, 0.025 μg/mL, 0.05 μg/mL, 0.1 μg/mL, 0.25 μg/mL, and 0.5 μg/mL, respectively. The IC50 value of Nedaplatin for growth inhibition of SBC-3 cells is 0.053 μg/mL.

体内研究：The sequential administration of 5-FU prior to nedaplatin or CDDP (FN or FC therapy) results in synergistically enhanced inhibition of tumour growth and prolonged survival in comparison with nedaplatin, CDDP or 5-FU monotherapy. Combined dosing of Nedaplatin with gemcitabine results in synergistically enhanced inhibition of tumor growth in the Ma44 tumor model. Nedaplatin plus Gemcitabine is also effective against Ma44 cells when given late in the therapy, a model for advanced disease. Potent augmentation of growth inhibition by Nedaplatin with Gemcitabine is also found with the NCI-H460 tumor model.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs817528	Nedaplatin	5mg	527.00	立即咨询
abs817528	Nedaplatin	10mg	785.00	立即咨询
abs817528	Nedaplatin	25mg	1682.00	立即咨询
abs817528	Nedaplatin	50mg	3095.00	立即咨询

产品更多信息请进入爱必信网站咨询

生化试剂 Nedaplatin由爱必信(上海)生物科技有限公司为您提供，如想了解更多关于生物分子 Nedaplatin的报价、规格、厂家等信息，欢迎来电或留言咨询。除供应Nedaplatin外，爱必信(上海)生物科技有限公司还可为您提供：

推荐专场