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价格: ¥ 4410
品牌:爱必信
供货周期: 7天
货号:abs821279
型号:98%
CAS:1835705-57-1
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抑制剂描述: 产品名称:E3 ligase Ligand-Linker Conjugates 10 产品别名:见爱必信官网 英文别名:E3 ligase Ligand-Linker Conjugates 10 靶点:VHL/PROTAC CAS:1835705-57-1 纯度:98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder) 描述:E3 ligase Ligand-Linker Conjugates 10 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. 溶解性: 体外研究: E3 ligase Ligand-Linker Conjugates 10 uses the VHL ligand. The linker is 6-2-2. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 10 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase . 体内研究:E3 ligase Ligand-Linker Conjugates 10 uses the VHL ligand. The linker is 6-2-2. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 10 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase .
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