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仪器信息网试剂标物生化试剂生物分子 Emodepside

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爱必信(上海)生物科技有限公司

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Emodepside

价格：￥ 2268

品牌：爱必信

供货周期： 7天

货号：abs820919

型号：98%

CAS：155030-63-0

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产品名称：Emodepside

产品别名：见爱必信官网

英文别名：Emodepside

靶点：Parasite

CAS：155030-63-0

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：Emodepside (PF 1022-221) is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity.

溶解性：

体外研究：

Emodepside is a semisynthetic derivative of PF1022A, which contains a morpholine attached in para position at each of both D-phenyllactic acids. Emodepside is efficacious against a variety of gastrointestinal nematodes. Emodepside binds to a presynaptic latrophilin receptor in nematodes. Emodepside produces a slow time-dependent (20 min), 4-aminopyridine sensitive, concentration-dependent hyperpolarization and increase in voltage-activated K currents. Emodepside has an inhibitory effect on spiking. Emodepside significantly inhibits the ryanodine increase in spike frequency between the 20 and 35 min period by 9.8 spikes/min. In the presence of emodepside, highly increased currents are observed without depolarization up to a threshold of 0 mV and without any additional stimuli to artificially increase [Ca 2+]i levels. These novel findings confirm that Slo-1 is a direct target of emodepside.

体内研究：Emodepside is a semisynthetic derivative of PF1022A, which contains a morpholine attached in para position at each of both D-phenyllactic acids. Emodepside is efficacious against a variety of gastrointestinal nematodes. Emodepside binds to a presynaptic latrophilin receptor in nematodes. Emodepside produces a slow time-dependent (20 min), 4-aminopyridine sensitive, concentration-dependent hyperpolarization and increase in voltage-activated K currents. Emodepside has an inhibitory effect on spiking. Emodepside significantly inhibits the ryanodine increase in spike frequency between the 20 and 35 min period by 9.8 spikes/min. In the presence of emodepside, highly increased currents are observed without depolarization up to a threshold of 0 mV and without any additional stimuli to artificially increase [Ca 2+]i levels. These novel findings confirm that Slo-1 is a direct target of emodepside.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs820919	Emodepside	5mg	2268.00	立即咨询
abs820919	Emodepside	50mg	11088.00	立即咨询

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