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仪器信息网试剂标物生化试剂生物分子 Artemisinin

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爱必信(上海)生物科技有限公司

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Artemisinin

价格：￥ 399

品牌：爱必信

供货周期：一周

货号：abs815898

规格：＞98%

CAS：63968-64-9

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抑制剂描述：

产品名称：Artemisinin

产品别名：见爱必信官网

英文别名：Artemisinin

靶点：HCV

CAS：63968-64-9

纯度：＞98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Artemisinin is a sesquiterpene endoperoxide which is a potent antimalarial agent.

溶解性：DMSO : 28.2 mg/mL (100 mM)
Ethanol : 21.2 mg/mL (75 mM)

体外研究：

Artemisinin (3.125-100 μM) concentration-dependently suppresses Aβ25-35 induced cytotoxicity in PC12 cells. Artemisinin (25 μM) suppresses Aβ25-35-induced LDH release, apoptosis and ROS production, attenuates Aβ-induced mitochondrial membrane potential loss and caspase 3/7 activity increase, and stimulates the phosphorylation of ERK1/2 in a time- and concentration-dependent manner in PC12 cell. ERK 1/2 pathway mediates the protect effects of artemisinin in PC12 cells. Artemisinin shows cytotoxic activity in MCF-7/Dox cell line with IC50 of 3.7±0.4 μg/mL after 24 h treatment. Besides, Artemisinin treatment of MCF-7 cells, sensitive and resistant to Dox and DDP, causes a decrease in expression of proteins such as LF, FTH1, and HEP. Artemisinin activates p38 MAPK-kinase cascade regardless of the oxidative stress due to inhibition of VEGF expression and cell migration. Artemisinin (50, 100 or 200 mg) significantly inhibits isoflurane-induced hippocampal neuronal loss, decreases caspase-3-positive cell counts and also cleaves caspase-3 expression, and modulates the expression of apoptosis pathway proteins. Artemisinin modulates JNK/ERK 1/2 signalling and histone acetylation. Artemisinin inhibits HCV replication in a dose-dependent manner with EC50 value of 167±38 μM. Artemisinin and its most potent analogues partially inhibit the in vitro replication of HCV by induction of reactive oxygen species (ROS). Artemisinin significantly inhibits VSMC proliferation in a dose-dependent manner. Artemisinin (1?mM) for 72?h significantly reduces the expression of proliferating cell nuclear antigen messenger RNA.

体内研究：Artemisinin (50, 100 or 200 mg/kg b.wt/day, p.o.) prevents isoflurane-induced working memory impairments as observed in T-maze test. Artemisinin enhances spatial navigation and memory of rats exposed to isoflurane. Artemisinin-treated rats exhibit markedly better performance in comparison with isoflurane-alone-exposed rats.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs815898	Artemisinin	50mg	399.00	立即咨询
abs815898	Artemisinin	200mg	693.00	立即咨询
abs815898	Artemisinin	100mg	484.00	立即咨询

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