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仪器信息网试剂标物生化试剂生物分子 Clevudine

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爱必信(上海)生物科技有限公司

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Clevudine

价格：￥ 2587

品牌：爱必信

供货周期：一周

货号：abs817771

规格：98%

CAS：163252-36-6

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抑制剂描述：

产品名称：Clevudine

产品别名：见爱必信官网

英文别名：Clevudine

靶点：HBV

CAS：163252-36-6

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：Clevudine is an antiviral drug for the treatment of hepatitis B.

溶解性：DMSO:52 mg/mL (199.83 mM)

体外研究：

Clevudine is a potent antiviral agent against HBV (EC50 0.1 μM in HepG2 2.2.15 cells) as well as EBV, which has low cytotoxicities in a variety of cell lines including MT2, CEM, H1 and HepG2 2.2.15 and bone marrow progenitor cells. Clevudine is metabolized in cells by the cellular thymidine kinase as well as deoxycytidine kinase to its monophosphate, and subsequently to the di- and triphosphate. Clevudine is known to act specifically on viral DNA synthesis, and its triphosphate inhibits the HBV DNA synthesis in a dose-dependent manner without being incorporated into the DNA or chain termination. Clevudine results in increase of the amounts of the diphosphate and triphosphate metabolites of these analogs. Clevudine monophosphate (L-FMAUMP) is a poorer substrate than its D-configuration anomer. Clevudine is readily phosphorylated to the corresponding 5'-triphosphate form of the compound in cell culture, which involves the mechanism of action of Clevudine.

体内研究：Clevudine is a potent antiviral agent against HBV (EC50 0.1 μM in HepG2 2.2.15 cells) as well as EBV, which has low cytotoxicities in a variety of cell lines including MT2, CEM, H1 and HepG2 2.2.15 and bone marrow progenitor cells. Clevudine is metabolized in cells by the cellular thymidine kinase as well as deoxycytidine kinase to its monophosphate, and subsequently to the di- and triphosphate. Clevudine is known to act specifically on viral DNA synthesis, and its triphosphate inhibits the HBV DNA synthesis in a dose-dependent manner without being incorporated into the DNA or chain termination. Clevudine results in increase of the amounts of the diphosphate and triphosphate metabolites of these analogs. Clevudine monophosphate (L-FMAUMP) is a poorer substrate than its D-configuration anomer. Clevudine is readily phosphorylated to the corresponding 5'-triphosphate form of the compound in cell culture, which involves the mechanism of action of Clevudine.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs817771	Clevudine	10mg	2587.00	立即咨询
abs817771	Clevudine	50mg	7842.00	立即咨询

产品更多信息请进入爱必信网站咨询

生化试剂 Clevudine由爱必信(上海)生物科技有限公司为您提供，如想了解更多关于生物分子 Clevudine的报价、规格、厂家等信息，欢迎来电或留言咨询。除供应Clevudine外，爱必信(上海)生物科技有限公司还可为您提供：

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