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仪器信息网试剂标物生化试剂生物分子 Isavuconazole

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Isavuconazole

价格：￥ 504

品牌：爱必信

供货周期：一周

货号：abs817476

规格：99%

CAS：241479-67-4

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抑制剂描述：

产品名称：Isavuconazole

产品别名：见爱必信官网

英文别名：Isavuconazole

靶点：Antifungal

CAS：241479-67-4

纯度：99%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：Isavuconazole(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557, exhibits MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata.

溶解性：10 mM in DMSO

体外研究：

Isavuconazole inhibits cytochrome P450 (CYP)–dependent 14α-lanosterol demethylation, which is essential for fungal cell membrane ergosterol synthesis. This blockade produces methylated sterols in the fungal membrane, altering its function and allowing the accumulation of ergosterol toxic precursors in the cytoplasm, which leads to cell death.

体内研究：Isavuconazonium sulfate, the prodrug of isavuconazole, is available in both intravenous and oral formulations. After intravenous infusion, the prodrug is broken down quickly to the active component, isavuconazole, and an inactive cleavage product. Following oral administration, plasma concentrations of the active compound reach maximum concentrations (Cmax) by 2–3 hours; the prodrug and cleavage product are not measurable in plasma after oral administration. In healthy adult volunteers, isavuconazole exhibits linear and dose-proportional pharmacokinetics. The oral bioavailability of isavuconazole is 98%. Absorption of isavuconazole is not affected by food intake. In addition to excellent bioavailability, isavuconazole serum concentrations show low intersubject variability. In healthy volunteers, the Cmax at steady state was 2.5 ± 1.0 μg/mL. Isavuconazole has a large volume of distribution, is >99% protein bound, and has a long terminal half-life of 100-130 hours. Metabolism of isavuconazole takes place in the liver via the CYP enzyme family, specifically CYP3A4 and CYP3A5 isoenzymes.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs817476	Isavuconazole	1mg	504.00	立即咨询
abs817476	Isavuconazole	5mg	793.00	立即咨询
abs817476	Isavuconazole	10mg	1220.00	立即咨询
abs817476	Isavuconazole	25mg	2033.00	立即咨询

产品更多信息请进入爱必信网站咨询

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