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仪器信息网试剂标物生化试剂生物分子 Bacitracin

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Bacitracin

价格：￥ 817

品牌：爱必信

供货周期：一周

货号：abs817108

CAS：1405-87-4

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抑制剂描述：

产品名称：Bacitracin

产品别名：见爱必信官网

英文别名：Bacitracin

靶点：Antibacterial

CAS：1405-87-4

纯度：

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, which disrupts both gram positive and gram negative bacteria by interfering with cell wall and peptidoglycan synthesis.

溶解性：Water : 100 mg/mL (70.98 mM)
DMSO : 100 mg/mL (70.98 mM)

体外研究：

Bacitracin is a potent antibiotic against gram-positive cocci, staphlococci, streptococci, corynebacteria, Treponema pallidum, T. vincenti, Actinomyces israeli, anaerobic cocci, clostridia, neisseria, most gonococci and meingococci, but it is relatively ineffective against most other gram-negative bacteria. Archaebacteria is also sensitive to Bacitracin. Of this group, Methanobacterium arbophilicum, M. M.O.H., M. O.H.G. and M. formicium showed inhibition by Bacitracin while Methanospirilum and Methanosarcina are insensitive to the antibiotic. Bacitracin affects a number of biochemical processes in bacteria, including metal ion transport, peptidoglycan synthesis, membrane permeability, and biosynthesis of inducible enzymes. Many of the biological properties of Bacitracin can be attributed to its high affinity for polyisoprenyl pyrophosphates. Aside from the antibiotic activity of the Bacitracins, these peptides have proven useful as a tool for investigating lipid-protein interactions at the molecular level. Bacitracin is also a known inhibitor of insulin degradation by both isolated cells and subcellular organelles, which inhibits the ability of purified glutathione-insulin transhydrogenase to split insulin into its constituent A and B chains. At concentrations of 90 and 300μM, Bacitracin inhibits 50 and 90%, respectively, of the degrading activity of the purified enzyme. Similarly, degradation by crude liver lysates is inhibited 50 and 90% by 70 and 250 μM Bacitracin, respectively. Bacitracin decreases both the Vmax and affinity of the enzyme for insulin. Bacitracin is able to inhibit the reductive function of the plasma membrane by against protein disulfide-isomerase. Bacitracin is able to induce inhibition of the cleavage of a disulfide-linked iodotyramine/poly(D-lysine) conjugate which bounds nonspecifically to the surface of CHO cells. Bacitracin also inhibits the cytotoxicity of diphtheria toxin, adisulfide-linked heterodimer that binds to a specific surface receptor and must undergo chain separation to exert its cytotoxicity.

体内研究：

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs817108	Bacitracin	25mg	817.00	立即咨询
abs817108	Bacitracin	100mg	1922.00	立即咨询
abs817108	Bacitracin	50mg	1210.00	立即咨询
abs817108	Bacitracin	200mg	2405.00	立即咨询

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