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仪器信息网试剂标物生化试剂生物分子 Isoniazid

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Isoniazid

价格：￥ 496

品牌：爱必信

供货周期：一周

货号：abs816984

规格：99%

CAS：54-85-3

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抑制剂描述：

产品名称：Isoniazid

产品别名：见爱必信官网

英文别名：Isoniazid

靶点：FAS

CAS：54-85-3

纯度：99%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Isoniazid is an?antibacterial?agent used primarily as a tuberculostatic.

溶解性：DMSO : 26 mg/mL (189.6 mM)
Ethanol : 26 mg/mL (189.6 mM)
Water : 25 mg/mL (182.3 mM)

体外研究：

Isoniazid is a prodrug that requires activation by the mycobacterial catalase-peroxidase enzyme (KatG) to an active form that then exerts a lethal effect on an intracellular target or targets. Isoniazid upregulates the expression of an operon containing five FAS II components, including kasA and acpM. Isoniazid results in the accumulation of ACP-bound lipid precursors to mycolic acids that are 26 carbons long and fully saturated. Isoniazid enters the mycobacterial cell by passive diffusion. Isoniazid itself is not toxic to the bacterial cell, but acts as a prodrug and is activated by the mycobacterial enzyme KatG, a multifunctional catalase-peroxidase that has other activities, including peroxynitritase and NADH oxidase. Isoniazid inhibits cell wall lipid synthesis, coupled with the findings that inhibitory INH adducts of NAD+/NADP+ are formed from the isonicotinoyl radical, leading the field away from this area. Isoniazid induces a concentration-dependent (0-40 mM) cytotoxic effect in day-1 treated HepG2 cells and not significantly affected by decreases in intracellular GSH concentrations.

体内研究：Isoniazid increases CYP2E1 protein, and the 6-hydroxychlorzoxazone formation rate is increased by 2.7 and 2.2-fold in liver and kidney, respectively. Isoniazid decreases liver and kidney 20-HETE content to 34% and 15.6% of control, respectively, without significantly altering tissue 19-HETE concentration.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs816984	Isoniazid	25mg	496.00	立即咨询
abs816984	Isoniazid	50mg	607.00	立即咨询
abs816984	Isoniazid	100mg	790.00	立即咨询
abs816984	Isoniazid	200mg	1105.00	立即咨询

产品更多信息请进入爱必信网站咨询

生化试剂 Isoniazid由爱必信(上海)生物科技有限公司为您提供，如想了解更多关于生物分子 Isoniazid的报价、规格、厂家等信息，欢迎来电或留言咨询。除供应Isoniazid外，爱必信(上海)生物科技有限公司还可为您提供：

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