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仪器信息网试剂标物生化试剂生物分子 Delamanid

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爱必信(上海)生物科技有限公司

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Delamanid

价格：￥ 789

品牌：爱必信

供货周期：一周

货号：abs813089

规格：98%

CAS：681492-22-8

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抑制剂描述：

产品名称：Delamanid

产品别名：见爱必信官网

英文别名：Delamanid

靶点：Antibacterial

CAS：681492-22-8

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex.

溶解性：DMSO ≥30 mg/mL

体外研究：

Delamanid potently inhibits the synthesis of mycolic acid, a long-chain fatty acid of the M. tuberculosis (mycobacterium tuberculosis) cell wall. Delamanid at concentrations of less than 5 μM shows no inhibitory effects on the efflux ABC transporters P-gp, BCRP, and BSEP or on the hepatic or renal SLC transporters OATPs, OCTs, and OATs. Delamanid is not metabolized by NADPH-dependent reactions, including those catalyzed by CYP enzymes, in human or animal liver microsomes. Also, delamanid has no inhibitory effects on the metabolism of exogenous CYP substrate compounds by eight CYP isoforms (CYP1A2, CYP2A6, CYP2B6, CYP2C8/9, CYP2C19, CYP2D6, CYP2E1, and CYP3A), even at a concentration of 100 μmol/liter, well above the therapeutic concentration.

体内研究：The water solubility of delamanid is poor and its absorption is increased more than two-fold by coadministration with food. The absolute bioavailability is unknown but estimated to be between 25% and 47%. In vivo, delamanid is more than 99% protein bound, with a high volume of distribution (Vz/F of 2100 L) and a half-life of 30-38 hours. Delamanid is excreted primarily in the stool, with less than 5% excretion in the urine. It is thought to be primarily metabolized by albumin, with secondary contributions from P450 enzymes, primarily CYP3A4. Animal studies indicate that delamanid is excreted in breast milk.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs813089	Delamanid	5mg	789.00	立即咨询
abs813089	Delamanid	10mg	1105.00	立即咨询
abs813089	Delamanid	50mg	4851.00	立即咨询

产品更多信息请进入爱必信网站咨询

生化试剂 Delamanid由爱必信(上海)生物科技有限公司为您提供，如想了解更多关于生物分子 Delamanid的报价、规格、厂家等信息，欢迎来电或留言咨询。除供应Delamanid外，爱必信(上海)生物科技有限公司还可为您提供：

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