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仪器信息网试剂标物生化试剂生物分子 Tamoxifen

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Tamoxifen

价格：￥ 336

品牌：爱必信

供货周期：一周

货号：abs815896

规格：99%

CAS：10540-29-1

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产品名称：Tamoxifen

产品别名：见爱必信官网

英文别名：Tamoxifen

靶点：ERR

CAS：10540-29-1

纯度：99%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Tamoxifen is an antagonist of the estrogen receptor in breast tissue.

溶解性：DMSO : 7.4 mg/mL (20 mM)
Ethanol : 37.2 mg/mL (100 mM)

体外研究：

TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D)

体内研究：Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs815896	Tamoxifen	100mg	336.00	立即咨询
abs815896	Tamoxifen	500mg	578.00	立即咨询

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