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仪器信息网试剂标物生化试剂生物分子 Nilutamide

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Nilutamide

价格：￥ 368

品牌：爱必信

供货周期：一周

货号：abs813919

规格：>98%

CAS：63612-50-0

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抑制剂描述：

产品名称：Nilutamide

产品别名：见爱必信官网

英文别名：Nilutamide

靶点：Androgen Receptor

CAS：63612-50-0

纯度：>98%

外观：见爱必信官网

保存方法：-20°C

描述：

Nilutamide (Nilandron, Anandron, RU 23908) is an androgen receptor (AR) blocker with an IC50 of 0.4 μM. The twofold stimulation of Shionogi cell proliferation caused by a 10-day exposure to 1 nM testosterone is competitively reversed by incubation with Nilutamide, at the IC50. Nilutamide at the IC50 values of 87 nM and in T-47D and ZR-75-1 cells blocks the marked increase in GCDFP-15 release induced by 1 nM testosterone.Nilutamide blocks the androgen induction of CYP27A1. Treatment of the HepG2 cells with dihydrotestosterone in presence of the AR antagonist Nilutamide almost completely abolishes the dihydrotestosterone-induced effect on the CYP27A1 promoter activity. Incubation with 100 μg/mL Nilutamide results in decreased movement of S. mansoni adults. Nilutamide inhibits hepatic cytochrome P-450 activity. Total worm burden reductions of 5.1%–35.6% are achieved with Nilutamide. The highest female worm burden reduction of 75.4% is observed with a 200 mg/kg dose of Nilutamide, while moderate female worm burden reductions of 22.5%–27.5% are observed following 50 mg/kg, 100 mg/kg and 400 mg/kg Nilutamide doses. At 400 mg/kg, Nilutamide reduced total and female worm burdens by 84.8% and 71.3%, respectively. Combinations of Nilutamide (100 mg/kg) and praziquantel (50 mg/kg or 100 mg/kg) reveals an increase in worm survival, above the level observed with praziquantel or Nilutamide monotherapy. However, a combination of Nilutamide (200 mg/kg) and praziquantel (100 mg/kg) produces statistically significant total and female worm burden reductions by 90.6% and 85.1%, respectively. Anandron (20 mg/kg/day) with even low doses of buserelin leads to an immediate decrease in prostate weight that is complete at 15 days. Nilutamide and Dasatinib has entered in a phase II clinical trial in the treatment of prostate cancer. Nilutamide plus bicalutamide, buserelin, cyproterone acetate, flutamide, goserelin or leuprolide acetate has entered in a phase III clinical trial in the treatme

溶解性：DMSO ：10 mM

体外研究：

体内研究：

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs813919	Nilutamide	10mg	368.00	立即咨询
abs813919	Nilutamide	50mg	630.00	立即咨询
abs813919	Nilutamide	200mg	865.00	立即咨询
abs813919	Nilutamide	100mg	481.00	立即咨询

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生化试剂 Nilutamide由爱必信(上海)生物科技有限公司为您提供，如想了解更多关于生物分子 Nilutamide的报价、规格、厂家等信息，欢迎来电或留言咨询。除供应Nilutamide外，爱必信(上海)生物科技有限公司还可为您提供：

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