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仪器信息网试剂标物生化试剂生物分子 Leukadherin 1

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爱必信(上海)生物科技有限公司

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Leukadherin 1

价格：￥ 2296

品牌：爱必信

供货周期：一周

货号：abs811450

规格：>98%

CAS：344897-95-6

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抑制剂描述：

产品名称：Leukadherin 1

产品别名：见爱必信官网

英文别名：Leukadherin 1

靶点：Integrin

CAS：344897-95-6

纯度：>98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Leukadherin 1 is an allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 ??M).

溶解性：DMSO 15 mg/mL (35.58 mM)
Water slightly soluble or insoluble
Ethanol slightly soluble or insoluble

体外研究：

Leukadherin-1 pretreatment reduces secretion of interferon (IFN)-γ, tumour necrosis factor (TNF) and macrophage inflammatory protein (MIP)-1β by monokine-stimulated NK cells. It also reduces secretion of IL-1β, IL-6 and TNF by Toll-like receptor (TLR)-2 and TLR-7/8-stimulated monocytes. Leukadherin-1 modulates NK cell cytokine secretion and does not modulate Syk activation in NK cells. LA1 increases CD11b/CD18-dependent cell adhesion to fibrinogen with 50% effective concentration (EC50, the effective concentration for a 50% increase in adhesion) values of 4 μM.

体内研究：Leukadherin-1 has potent anti-inflammatory effects in a range of animal models, including an autoimmune nephritis model, without obvious short-term side effects. Leukadherin-1 (LA1) increases leukocyte adhesion, preventing their transmigration and tissue recruitment in vivo. LA1 treatment reduces interstitial leukocyte infiltration in the allograft, reduces neointimal hyperplasia and glomerular damage, and prolongs graft survival from 48.5% (CsA only) to 100% (CsA and LA1) on day 60 in a mouse model of fully MHC-mismatched orthotopic kidney transplantation.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs811450	Leukadherin 1	50mg	2296.00	立即咨询
abs811450	Leukadherin 1	10mg	832.00	立即咨询
abs811450	Leukadherin 1	100mg	3676.00	立即咨询

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