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仪器信息网试剂标物生化试剂生物分子 Caffeic Acid Phenethyl Ester

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Caffeic Acid Phenethyl Ester

价格：￥ 933

品牌：爱必信

供货周期： 7天

货号：abs817781

型号：＞98%

CAS：104594-70-9

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抑制剂描述：

产品名称：Caffeic Acid Phenethyl Ester

产品别名：见爱必信官网

英文别名：Caffeic Acid Phenethyl Ester

靶点：Phenylpropanoids

CAS：104594-70-9

纯度：＞98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.

溶解性：DMSO :57 mg/mL (200.48 mM)

体外研究：

Caffeic acid phenethyl ester blocks NF-κB activation induced by phorbol ester, ceramide, okadaic acid, and hydrogen peroxide by preventing the translocation of the p65 subunit of NF-κB to the nucleus. In a series of tumor cell lines, Caffeic acid phenethyl ester shows promising antiproliferative activity with EC50 of 1.76, 3.16, 13.7, and 44.0 μM against murine colon 26-L5, murine B16-BL6 melanoma, human HT-1080 fibrosarcoma and human lung A549 adenocarcinoma cell lines, respectively. Caffeic acid phenethyl ester, as a potent antioxidant, exerts its anti-apoptotic effect in cerebellar granule cells by blocking ROS formation and inhibiting caspase activity. Moreover, Caffeic acid phenethyl ester attenuates the pro-inflammatory phenotype of LPS-stimulated HSCs, and LPS-induced sensitization of HSCs to fibrogenic cytokines by inhibiting NF-κB signaling.

体内研究：In vivo, Caffeic acid phenethyl ester (10 mg/kg, i.p.) inhibits the growth and angiogenesis of primary tumors in C57BL/6 and BALB/c mice inoculated with Lewis lung carcinoma, colon carcinoma, and melanoma cells. Caffeic acid phenethyl ester (5, 10, 20 mg/kg) also shows immunomodulatory effects in vivo by decreasing thymus weight and/or cellularity of thymus and spleen.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs817781	Caffeic Acid Phenethyl Ester	50mg	933.00	立即咨询
abs817781	Caffeic Acid Phenethyl Ester	200mg	1387.00	立即咨询

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