获取电话
诱导协同刺激分子配体CD275抗体
英文名称 ICOS ligand
中文名称 诱导协同刺激分子配体CD275抗体
别 名 B7 H2; B7 homolog 2; B7 homologue 2; B7 like protein Gl50; B7 related protein 1; B7-like protein Gl50; B7-related protein 1; B7-H2; B7H2; B7RP 1; B7RP-1; B7RP1; CD 275; CD275; CD275 antigen; GL 50; GL50; ICOS L; ICOS LG; ICOS ligand; ICOSL; ICOSL_HUMAN; Icoslg; Inducible T cell co stimulator ligand; KIAA0653; LICOS; Transmembrane protein B7 H2 ICOS ligand; ICOSLG; ICOS ligand-like; ICOS ligand.
研究领域 免疫学 转录调节因子 细胞表面分子
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Rat,
产品应用 WB=1:500-2000 ELISA=1:500-1000 Flow-Cyt=1μg/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ICOS ligand:19-120/302
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 ICOS ligand is a member of the B7 family and the immunoglobulin superfamily. Human ICOS ligand is expressed by activated monocytes/macrophages and dendritic cells. It binds to a CD28 like receptor, inducible costimulator molecule (ICOS, AILIM, CRP-1), which is expressed by activated T cells. This interaction plays an important role in the T cell costimulation pathway.
B7协同刺激分子及其相应受体结合所产生的信号在调节T细胞活化及效应性细胞因子分泌中起重要作用，具有负性调节作用的协同刺激分子对免疫应答的适度进行、防止自身免疫疾病的发生具有重要作用。
B7H2可协同刺激CD14 + 细胞增殖，并分泌IL-4、IL-5、IFN-β、TNF-α、GM-CSF和IL-10等细胞因子，但不能协同刺激T细胞上调IL-2的分泌。
