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德国耶拿 multi N/C 3100 TOC总有机碳/总氮分析仪型号： multi N/C 3100 -
Hitachi日立CT15RE台式离心机型号： CT15RE -
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珀金埃尔默PerkinElmer NexION 1100/1000G ICP-MS型号： NexION 1100/1000G ICP-MS
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载脂蛋白A1抗体
英文名称 APOA1
中文名称 载脂蛋白A1抗体
别 名 Apo-AI; ApoA I; ApoA-I; APOA1_HUMAN; Apolipoprotein A-I(1-242); Apolipoprotein A1; Apolipoprotein A 1; Apolipoprotein AI; Apolipoprotein A I; Brp14; Ltw1; Lvtw1; Sep1; Sep2.
研究领域 肿瘤 心血管 细胞生物 免疫学 神经生物学 信号转导 脂蛋白 新陈代谢
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse,
产品应用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
细胞定位 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human APOA1:151-250/267
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 Apolipoprotein A I promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18 amino acid signal peptide is removed co-translationally and a 6 amino acid propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease. The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.
APOA1是检测高密度脂蛋白的主要形式，APOA1降低被认为是心、脑血管疾病的危险因素。
APOA1升高：常见于肝脏疾病、肝外胆道阻塞、人工透析。
APOA1降低：常见于冠心病、未控制的糖尿病、肾病综合征、营养不良、活动性肝炎、肝功能低下、动脉粥样硬化、高脂蛋白血症。
