获取电话LC-MS/MS检测类固醇激素
类固醇激素是由胆固醇合成的。他们大部分是由肾上腺、睾丸或卵巢产生的。它们在与不同目标器官的特定细胞受体结合后，完成了广泛的生理功能。主要涉及碳水化合物、脂质和蛋白质代谢、应激反应、水和矿物质平衡调节、生殖过程和第二性征的发育。因此，类固醇激素也与各种疾病有关，如肾上腺肿瘤、肾上腺生殖器综合症（CAH）、库兴氏综合征或多囊卵巢综合征。合成类固醇用于治疗急性和慢性疾病，如性腺功能障碍、过敏和免疫反应抑制。在诊断和评估病理条件和治疗反应方面，类固醇的定量分析是必不可少的。RECIPE开发了一种快速简单的类固醇定量分析LC-MS/MS方法，该方法涵盖了相关的类固醇激素。因此，能够识别出单个类固醇谱的显著变化。
类固醇激素完整试剂盒可检测如下激素：
* 皮质醇/Cortisol
* 睾丸素/Testosterone
* 雄烯二酮/Androstenedione
* 11-脱氧皮质醇/11-Deoxycortisol
* 21-脱氧皮质醇21-Deoxycortisol
* 17-孕酮/17-OH-Progesterone
* 21-孕酮/21-OH-Progesterone
* 脱氢表雄酮/DHEAS
Steroids in Serum / Plasma
Steroid hormones are synthesised from cholesterol. The majority of these powerful molecules are produced by the adrenal glands, testes or ovaries. They fulfil a wide range of physiological functions after binding to specific cell receptors of various target organs. Mainly, they are involved in the carbohydrate, lipid and protein metabolism, stress response and in the regulation of the water and mineral balances, in reproductive processes and the development of secon dary sex characteristics. Consequently, steroid hormones are also involved in a variety of disea ses, like adrenal tumors, the Adrenogenital syndrome (CAH), the Cushing’s syndrome or the Polycystic Ovarian Syndrome. The quantitative profiling of steroids is essential in diagnosis and evaluation of pathologic conditions and therapeutic responses.
RECIPE developed a fast and simple quantitative Steroid profiling LC-MS/MS method that covers the most relevant steroid hormones.
* Fast and easy sample preparation
* Injection interval of 6 min
* Includes second tier parameters for CAH testing
样品前处理步骤：
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