磷酸化结节性硬化蛋白抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化结节性硬化蛋白抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between磷酸化结节性硬化蛋白抗体 hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.

磷酸化结节性硬化蛋白抗体Also known as:

TSC2(phospho S540); Tuberin (Phospho Ser540); Tuberin (Phospho S540); Phospho TSC2 (Ser540); P-Tuberin/TSC2 (Ser1254); P-TSC2 (Ser1254); FLJ43106; LAM; TSC2; TSC2_HUMAN; TSC4; Tuberin; Tuberous sclerosis 2 protein.

Specificity:

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Rabbit Polyclonal IgG,磷酸化结节性硬化蛋白抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human Tuberin around the phosphorylation site of Ser540.

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磷酸化结节性硬化蛋白抗体Predicted Molecular Weight: 200kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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