Quantity size:
0.2ml
Concentration:
1mg/ml 初生多肽相关复合物亚单位α,肌肉特异型蛋白抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
NACA1, NACA2 and NACAP1 are members of the nascent polypeptide-associated complex (NAC) α subunit family that participate in preventing inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). As nascent polypeptide chains emerge from the ribosome, NACA proteins bind to these chains and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides初生多肽相关复合物亚单位α,肌肉特异型蛋白抗体 to the ER. Members of the α-NAC subunit family have sequence similarities with transcription-regulating proteins and are suggested to function as transcriptional coactivators potentiating c-Jun-mediated transcription. Most NACA proteins localize to both nucleus as well as cytoplasm, and contain NAC-A/B (NAC-α/β) and UBA (ubiquitin-assoc初生多肽相关复合物亚单位α,肌肉特异型蛋白抗体iated) domains. The UBA domain is associated with proteins involved in the ubiquitin-proteasome pathway for protein degradation.
Also known as:
初生多肽相关复合物亚单位α,肌肉特异型蛋白抗体NACAM_HUMAN; Nascent polypeptide-associated complex subunit alpha, muscle-specific form; Alpha-NAC, muscle-specific form; skNAC; skNAC; Gm1878; AL022831; AL024382; mKIAA0363.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Dog, Sheep, .
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初生多肽相关复合物亚单位α,肌肉特异型蛋白抗体Immunogen: KLH conjugated synthetic peptide derived from human Alpha-NAC, muscle-specific form.
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Predicted Molecular Weight: 229kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
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