His 结构域内含酪氨酸磷酸酶蛋白抗体

Quantity size:

0.2ml

Concentration:

1mg/ml His 结构域内含酪氨酸磷酸酶蛋白抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

HD-PTP is a 1,636 amino acid protein encoded by the human gene PTPN23. HD-PTP belongs to the protein-tyrosine phosphatase family, non-receptor class subfamily. It contains one BRO1 domain, two TPR repeats and one tyrosine-protein phosphatase domain. The C-terminal region contains the PTP-like domain, whereas the N-terminal region contains the two TPR regions.His 结构域内含酪氨酸磷酸酶蛋白抗体  These regions are homologous to the yeast protein, BRO1, which is involved in the mitogen-activated protein kinase signaling pathway. Similarly, HD-PTP is believed to act as a negative regulator of Ras-mediated mitogenic activity and is phosphorylated upon DNA damage, probably by ATM or ATR. HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor (VEGF) has no affect on protein levels, Fibroblast Growth Factor-2 (FGF-2) induces HD-PTP degradation via the proteasome system.

His 结构域内含酪氨酸磷酸酶蛋白抗体 Also known as:

DKFZP564F0923; EC 3.1.3.48; HD PTP; HD-PTP; HDPTP; His domain containing protein tyrosine phosphatase; His domain protein tyrosine phosphatase; His domain-containing protein tyrosine phosphatase; KIAA1471; Protein tyrosine phosphatase non receptor type 23; protein tyrosine phosphatase non-receptor type 23; Protein tyrosine phosphatase TD 14; protein tyrosine phosphatase TD14; PTN23_HUMAN; PTP TD14; PTP-TD14; PTPN 23; PTPN23;His 结构域内含酪氨酸磷酸酶蛋白抗体  Tyrosine protein phosphatase non receptor type 23; Tyrosine-protein phosphatase non-receptor type 23.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Pig, .

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Immunogen: KLH conjugated synthetic peptide derived from human HDPTP.

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His 结构域内含酪氨酸磷酸酶蛋白抗体 Predicted Molecular Weight: 179kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:20-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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