磷酸化胞吞再循环相关衔接蛋白CENTB1抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化胞吞再循环相关衔接蛋白CENTB1抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

ACAP1 is a member of the ADP ribosylation factor family of ARF6 GTPase-activating proteins (GAP). GAPs are important regulators of Arf function by controlling the return of ARF to its inactive state. ACAP1 is related to AGAP1 and ASAP1, and all three proteins are similarly expressed in fibroblast cells such as NIH/3T3. Internalization and recycling of integrin receptors is important in cell adhesion and migration modulation, and once inside a cell,磷酸化胞吞再循环相关衔接蛋白CENTB1抗体 proteins and membranes are transported to the endosome where they are sorted for recycling or degradation. ACAP1 promotes cargo sorting by associating directly to recycling cargo proteins. Preventing this interaction inhibits protein recycling. ACAP1 binds transferrin receptors, promoting their transport to the plasma membrane from the endosome. Akt induced phosphorylation of ACAP1 at Ser 554 regulates ACAP1 interaction to integrin in endosomes, and downregulation of Akt or ACAP1 may inhibit cell migration on Fibronectin.

磷酸化胞吞再循环相关衔接蛋白CENTB1抗体Also known as:

CENTB1 (phospho S554); p-CENTB1 (phospho S554); ACAP1 (phospho S554); p-ACAP1 (phospho S554); ACAP 1 (phospho S554);p-ACAP1 (phospho S554) ; ACAP1; ACAP1_HUMAN; ANK repeat and PH domain-containing protein 1; Arf GAP with coiled coil ANK repeat and PH domains 1; Arf GAP with coiled coil, ankyrin repeat, and pleckstrin homology domains 1; Arf-GAP with coiled-coil; Arf-GAP with coiled-coil,磷酸化胞吞再循环相关衔接蛋白CENTB1抗体 ANK repeat and PH domain-containing protein 1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; CENT B1; Centaurin beta 1; Centaurin-beta-1; CENTB 1; Cnt b1; Cnt-b1; Cntb1; KIAA0050.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, Sheep, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human CENTB1 around the phosphorylation site of Ser554.

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磷酸化胞吞再循环相关衔接蛋白CENTB1抗体Predicted Molecular Weight: 81kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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