细胞因子信号传导抑制蛋白2抗体

细胞因子信号传导抑制蛋白2抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

细胞因子信号传导抑制蛋白2抗体产品介绍

    Socs2(suppressor of cytokine signaling 1) 细胞因子信号传导抑制蛋白(suppressor of cytokine signaling, SOCS)家族是一类由细胞产生并反馈性阻断细胞因子信号转导过程的负性调节因子，SOCS2可抑制IL-6、LIF、OSM、INF-γ以及GH等多种细胞因子的信号转导，对体内多种免疫反应的激活起调控作用。SOCS2异常表达与多种疾病的发病相关，在急慢性白血病、类风湿性关节炎、肝硬化和肝癌的发病中起重要作用；对信号转导，特别是JAKSTAT通路的负调控作用已被肯定。 

    The eight members of the recently identified Suppressor of Cytokines Signalling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signalling in different ways.

    SOCS2 is capable of inhibiting cytokine signalling by interleukin-6 (IL-6) and growth hormone. SOCS2 interacts with the phosphorylated insulin-like growth factor (IGF-I) receptor, where it may play a regulatory role in cellular growth, differentiation, and inhibition of apoptosis via the Ras and PI3K signalling pathways. In humans, SOCS2 mRNA is expressed widely in both foetal and adult tissues, including foetal kidney and adult heart, skeletal muscle, pancreas, and liver. In rats, SOCS2 mRNA exhibits high levels of expression in liver and heart, and in the mouse nervous system, SOCS2 is expressed exclusively by neurons, where it is switched on developmentally in concordance with neuronal differentiation. 

    Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 2, not like SOCS 1 and SOCS 3, regulates postnatal growth, likely through its ability to influence the GH / IGF 1axis, although they might have overlapping actions. 

    mol wt:23kDa 
    Other Aliases: 
    suppressor of cytokine signaling 2; suppressor of cytokine signaling SOCS2; CIS2; Cish2; SSI-2; SOCS2; STATI2

细胞因子信号传导抑制蛋白2抗体

hz-1271R HtrA2/Omi  线粒体丝氨酸蛋白酶抗体

hz-0233R TRT/TERT  端粒酶反转录酶抗体

hz-0650R human serum  人血清抗体

hz-0464R Hydroxyethyk starch/HES 130/0.4  羟乙基淀粉抗体

hz-0618R COX10  细胞色素c氧化酶10抗体

hz-3951R Cytochrome B/MT-CYB  细胞色素B抗体

hz-5115R Cytochrome b5/CYB5A  细胞色素b5抗体

hz-0902R IAA (Indole-3-Acetic Acid)  吲哚乙酸抗体/植物生长素抗体

hz-0902M IAA  吲哚乙酸/植物生长素单克隆抗体

hz-1252R API5  凋亡抑制因子5抗体

hz-0284R IASPP  肿瘤细胞凋亡ASPP家族的另一个成员抗体

hz-1363R AIF1/IBa-1  离子钙接头蛋白抗体

hz-0214R ICAD/DFF-45 Beta  Caspase激活的脱氧核糖核酸酶抑制剂抗体

hz-2583R ICOS/CD278  诱导协同刺激分子CD278抗体

hz-0018M IDE  胰岛素降解酶抗体

hz-0018R IDE  胰岛素降解酶抗体

hz-3947R IDH2  草酰琥珀酸脱羧酶抗体

hz-3946R IDH3A  草酰琥珀酸脱羧酶α抗体

hz-5073R IDI1  异戊烯焦磷酸1抗体

hz-0825R IFABP  小肠型脂肪酸结合蛋白抗体

hz-0898R IFABP  小肠型脂肪酸结合蛋白抗体

hz-5059R FABP6  回肠脂肪酸结合蛋白抗体

hz-1472R IFI16  γ干扰素诱导蛋白16抗体

hz-1031R IFITM1/CD225  干扰素诱导跨膜蛋白1抗体

hz-4116R IFNAR1  干扰素α受体抗体

hz-5457R phospho-IFNAR1(Ser535+Ser539)  磷酸化干扰素α受体抗体

hz-1578R IFN-Alpha/IFNA1/IFNA13/Interferon alpha 1  干扰素α抗体

hz-0536R IFN-Alpha 2b/Interferon alpha 2/INFA2  干扰素α2b抗体

hz-0787R IFN-Beta  干扰素β抗体

hz-0784R IFN-β  干扰素β抗体

hzm-0388M IFN gamma(F2E4)  γ-干扰素单克隆抗体

hz-0481R IFN gamma  干扰素-γ抗体

hz-0480R IFN gamma  干扰素-γ抗体

hz-1463R IFNGR1/CD119  干扰素-gamma受体1抗体