获取电话抗磷酸化信号转导与转录激活因子1抗体产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
抗磷酸化信号转导与转录激活因子1抗体产品介绍
转录调节因子（Transcriptin Regulators）
STATs (signal transducers and activators of transcription) were originally discovered as two proteins (STAT1 and STAT2) which were involved in interferon alpha (IFN alpha) and IFN gamma signal transduction. Since then, several additional STAT proteins have been identified (STAT3, 4, 5a, 5b, and 6). STATs undergo tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. In some cases this process is mediated by JAK Kinases (Janus Kinases 1, 2, and 3). For maximum activation of these proteins, phosphorylation at specific tyrosine and serine residues may be required in STAT1 alpha, 3, 4, and 5.
Specific functions of the STAT proteins are poorly defined at this time. They are thought to be involved in a variety of systems including antiviral responses and cell transformation. STAT1 deficient knock-out mice are unable to induce IFN regulated genes and are extremely susceptible to viral diseases. After phosphorylation, STAT1 and STAT2 form heterodimers that function as more potent inducers of transcription than the STAT1 homodimer.
STAT1 is known to associate with the transcription factors p48, Sp1, and p300. STAT1 is activated by peptide hormones, growth factors and cytokines, particularly cytokines of the interferon family. STAT1 alpha and STAT1 beta isoforms arise by alternative splicing of a single gene. The only difference between the two proteins is that STAT1 beta lacks 38 carboxy terminal amino acids. Contained within these 38 terminal amino acids of STAT1 alpha is a critical serine residue (Ser 727) whose phosphorylation is required for maximal transcription activity induced by IFN gamma.
Also known as:
DKFZp686B04100 ISGF 3; Signal transducer and activator of transcription 1 91kDa; Signal transducer and activator of transcription 1 alpha/beta; Signal Transductor and Activator of Transcription 1; STAT 1; STAT 91; STAT91; Transcription factor ISGF 3 components p91 p84
抗磷酸化信号转导与转录激活因子1抗体
hz-4071R phospho-C CBL(Tyr674) 磷酸化原癌基因CBL2抗体
hz-0039R ADNP/NAP 活性依赖的神经保护肽抗体
hz-4072R Cphospho-C CBL(Tyr700) 磷酸化原癌基因CBL2抗体
hz-1225R ADORA3 腺苷受体A3抗体
hz-2640R ADO 2-氨基乙硫醇双加氧酶抗体
hz-2203R Integrin Alpha V 整合素αV抗体
hz-5149R CPI17 alpha 蛋白磷酸激酶PKC/CPI-17抗体
hz-4073R phospho-CPI17 alpha (Thr38) 磷酸化蛋白磷酸激酶PKC/CPI-17抗体
hz-1062R ADRA2 ADRA2肾上腺素能受体2抗体
hz-0498R ADRB1 肾上腺素能受体β1抗体
hz-5150R APE/Girdin 肌动蛋白结合蛋白Girdin抗体
hz-5835R Drebrin 脑发育调节蛋白抗体
hz-5152R DAG1 肌萎缩相关蛋白DAG1抗体
hz-0947R ADRB2 肾上腺素能受体β2抗体（β2-AR ）
hz-3002R phospho-ADRB2(Ser346) 磷酸化肾上腺素能受体β2抗体
hz-5211R phospho-ADRB2 (Ser261) 磷酸化肾上腺素能受体β2抗体
hz-4075R phospho-DAG1 (Tyr892) 磷酸化肌萎缩相关蛋白DAG1抗体
hz-6026R SynCAM 细胞粘附分子1抗体
hz-6027R CADM3/IGSF4B 细胞粘附分子3抗体
hz-5995R CAMTA1 钙调蛋白结合转录激活因子1抗体
hz-5996R CDC4/FBW7/SEL10 肿瘤抑制因子FBW7抗体
hz-5997R CADM 4 细胞粘附分子4抗体
hz-5998R DAB2IP Dab2相互作用蛋白抗体
hz-5999R DAB2 信号转导功能磷蛋白DAB2抗体
hz-1063R ADRB3/beta 3 Adrenergic Receptor β3肾上腺素能受体抗体
hz-6000R DACH1 细胞命运决定因子DACH1抗体
hz-6001R DRG1 GTP发育调控结合蛋白1抗体
hz-6002R DNAJB4/HSP40 homolog 热休克蛋白家族40抗体
hz-6003R DAL1/EPB41L3 细胞骨架4.1蛋白家族DAL1抗体
hz-6004R MIG6/ERRFI1 有丝分裂原诱导基因6抗体
hz-6005R EXTL 外生性骨疣样蛋白2抗体
hz-6006R FBXO31 F-box蛋白家族FBXO31抗体
hz-6007R FLCN/BHD/Folliculin 卵巢滤泡激素抗体（BHD综合征）
hz-6008R GADD45GIP1 GADD45γ相互作用蛋白1抗体
