缺陷性分配同源物α抗体

英文名称    PAR6    

中文名称    缺陷性分配同源物α抗体    

别    名    0710008C04Rik; 2610010A15Rik; Par 6 partitioning defective 6 C elegans homolog alpha; Par 6 partitioning defective 6 homolog alpha; Par 6 partitioning defective 6 homolog alpha C elegans; PAR 6A; PAR-6 alpha; PAR-6; par-6 family cell polarity regulator alpha; PAR-6A; PAR6; PAR6A_HUMAN; PAR6alpha; PAR6C; Pard6a; Partitioning defective 6 homolog alpha; partitioning-defective protein 6; partitioning-defective protein 6, C. elegans, homolog of, alpha; Tax interacting protein 40; Tax interaction protein 40; TAX40; TIP 40; TIP-40; TIP40.    

缺陷性分配同源物α抗体    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  染色质和核信号  信号转导  干细胞  细胞粘附分子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    37kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PAR6    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

缺陷性分配同源物α抗体产品介绍    background:
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Function:
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Subunit:
Interacts with MAP2K5. Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 ('Thr-359' phosphorylated form) and PRKCI.

Subcellular Location:
Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.

Tissue Specificity:
Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.

Post-translational modifications:
Phosphorylated by the TGF-beta receptor.

Similarity:
Belongs to the PAR6 family. 
Contains 1 OPR domain. 
Contains 1 PDZ (DHR) domain. 
Contains 1 pseudo-CRIB domain.

Gene ID:
50855

Database links:

Entrez Gene: 50855 Human

Entrez Gene: 56513 Mouse

Entrez Gene: 307799 Rat

Omim: 607484 Human

SwissProt: Q9NPB6 Human

SwissProt: Q9Z101 Mouse

SwissProt: Q6B4M5 Rat

Unigene: 112933 Human

Unigene: 472753 Mouse

Unigene: 16053 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

缺陷性分配同源物α抗体

hz-0311R-AF350 Rabbit Anti-Biotin/Alexa Fluor 350  Alexa Fluor 350标记的兔抗生物素抗体IgG

hz-0311R-AF488 Rabbit Anti-Biotin/Alexa Fluor 488  Alexa Fluor 488标记的兔抗生物素抗体IgG

hz-0311R-AF555 Rabbit Anti-Biotin/Alexa Fluor 555  Alexa Fluor 555标记的兔抗生物素抗体IgG

hz-0311R-AF647 Rabbit Anti-Biotin/Alexa Fluor 647  Alexa Fluor 647标记的兔抗生物素抗体IgG

hz-0311R-PE-hzy5.5 Rabbit Anti-Biotin/PE-Cy5.5  PE-Cy5.5标记的兔抗生物素抗体IgG

hz-0311R-PE-hzy7 Rabbit Anti-Biotin/PE-Cy7  PE-Cy7标记的兔抗生物素抗体IgG

hz-0311R-FIThz Rabbit Anti-Biotin/FITC  FITC标记的兔抗生物素抗体IgG

hz-0311R-Gold Rabbit Anti-Biotin/Gold  胶体金标记的兔抗生物素抗体IgG

hz-0311R-RBIThz Rabbit Anti-Biotin/RBITC  罗丹明标记的兔抗生物素抗体IgG

hz-0311R-HRP Rabbit Anti-Biotin/HRP  辣根过氧化物酶标记的兔抗生物素抗体IgG

hz-0311R-AP Rabbit Anti-Biotin/AP  碱性磷酸酶（AP）标记的兔抗生物素抗体IgG

hz-0311R-Bio Rabbit Anti-Biotin/Bio  生物素标记的兔抗生物素抗体IgG

hz-0326R-Bio Rabbit Anti-Bov IgG/Bio  生物素标记的兔抗牛IgG 

hz-0326R-hzy3 Rabbit Anti-Bov IgG/Cy3  Cy3标记的兔抗牛IgG 

hz-0326R-hzy5 Rabbit Anti-Bov IgG/Cy5  Cy5标记的兔抗牛IgG 

hz-0326R-hzy5.5 Rabbit Anti-Bov IgG/Cy5.5  Cy5.5标记的兔抗牛IgG 

hz-0326R-hzy7 Rabbit Anti-Bov IgG/Cy7  Cy7标记的兔抗牛IgG 

hz-0326R-PE Rabbit Anti-Bov IgG/PE  PE标记的兔抗牛IgG 

hz-0326R-PE-hzy3 Rabbit Anti-Bov IgG/PE-Cy3  PE-Cy3标记的兔抗牛IgG 

hz-0326R-PE-hzY5 Rabbit Anti-Bov IgG/PE-CY5  PE-CY5标记的兔抗牛IgG 

hz-0326R-APhz Rabbit Anti-Bov IgG/APC  APC标记的兔抗牛IgG 

hz-0326R-AF350 Rabbit Anti-Bov IgG/Alexa Fluor 350  Alexa Fluor 350标记的兔抗牛IgG 

hz-0326R-AF488 Rabbit Anti-Bov IgG/Alexa Fluor 488  Alexa Fluor 488标记的兔抗牛IgG 

hz-0326R-AF555 Rabbit Anti-Bov IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗牛IgG 

hz-0326R-AF647 Rabbit Anti-Bov IgG/Alexa Fluor 647  Alexa Fluor 647标记的兔抗牛IgG 

hz-0326R-AP Rabbit Anti-Bov IgG/AP  碱性磷酸酶（AP）标记的兔抗牛IgG 

hz-0326R-HRP Rabbit Anti-Bov IgG/HRP  辣根过氧化物酶标记的兔抗牛IgG 

hz-0326R-PE-hzy5.5 Rabbit Anti-Bov IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗牛IgG 

hz-0326R-PE-hzy7 Rabbit Anti-Bov IgG/PE-Cy7  PE-Cy7标记的兔抗牛IgG 

hz-0326R-Gold Rabbit Anti-Bov IgG/Gold  胶体金标记的兔抗牛IgG 

hz-0326R-RBIThz Rabbit Anti-Bov IgG/RBITC  罗丹明标记的兔抗牛IgG 

hz-0326R-FIThz Rabbit Anti-Bov IgG/FITC  FITC标记的兔抗牛IgG 

hz-0327R-FIThz Rabbit Anti-Bovine IgM/FITC  FITC标记的兔抗牛IgM

hz-0327R-RBIThz Rabbit Anti-Bovine IgM/RBITC  罗丹明标记的兔抗牛IgM