获取电话英文名称 PTPN22
中文名称 蛋白酪氨酸磷酸酶非受体型22抗体
别 名 tyrosine-protein phosphatase non-receptor type 22; Hematopoietic cell protein tyrosine phosphatase 70Z PEP; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; Lymphoid specific protein tyrosine phosphatase; lymphoid-specific, inducible human protein tyrosine phosphatase; Lyp 1; Lyp 2; LyP; Lyp1; Lyp2; LyPTP; OTTHUMP00000013720; OTTHUMP00000013721; OTTHUMP00000233450; OTTHUMP00000233451; PEP; PEST-domain phosphatase; Protein tyrosine phosphatase non receptor type 22 (lymphoid); Protein tyrosine phosphatase non receptor type 22; Protein tyrosine phosphatase non receptor type 8; Protein tyrosine phosphatase non receptor type 8, formerly; PTN22_HUMAN; PTPN 22; PTPN 8; Ptpn22; PTPN8; PTPN8, formerly; Tyrosine-protein phosphatase non-receptor type 22.
蛋白酪氨酸磷酸酶非受体型22抗体
说 明 书 0.2ml
研究领域 细胞生物 信号转导 激酶和磷酸酶
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, Cat,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
细胞定位 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTPN22
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
蛋白酪氨酸磷酸酶非受体型22抗体 产品介绍 background:
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
Function:
Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.
Post-translational modifications:
Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases.
Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
Contains 1 tyrosine-protein phosphatase domain.
Database links:
Entrez Gene: 483124 Dog
Entrez Gene: 100717611 Guinea pig
Entrez Gene: 100059247 Horse
Entrez Gene: 26191 Human
Entrez Gene: 19260 Mouse
Entrez Gene: 295338 Rat
Omim: 600716 Human
SwissProt: Q9Y2R2 Human
SwissProt: P29352 Mouse
Unigene: 535276 Human
Unigene: 395 Mouse
Unigene: 22891 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白酪氨酸磷酸酶非受体型22抗体
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