获取电话英文名称 Reelin
中文名称 络丝蛋白抗体
别 名 Reelin; Reeler; RELN; RL; LIS2; PRO1598; RELN_HUMAN.
络丝蛋白抗体
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 免疫学 神经生物学 细胞凋亡
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Guinea Pig,
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 400-450;300;180-200kDa
细胞定位 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human RELN
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
络丝蛋白抗体产品介绍 background:
Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in “reeler” mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1 in a signaling pathway that controls cell positioning in the developing brain and is also thought to be a direct effector of the neurotrophin BDNF.
Function:
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined.
Subcellular Location:
Secreted
Tissue Specificity:
High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level).
Post-translational modifications:
N-glycosylated; more than 90% of the glycans are sialylated.
Similarity:
Belongs to the ALB/AFP/VDB family.
Contains 3 albumin domains.
Gene ID:
5649
Database links:
Entrez Gene: 5649 Human
Entrez Gene: 19699 Mouse
Entrez Gene: 24718 Rat
Omim: 600514 Human
SwissProt: P78509 Human
SwissProt: Q60841 Mouse
SwissProt: P58751 Rat
Unigene: 655654 Human
Unigene: 425236 Mouse
Unigene: 98353 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
络丝蛋白抗体
hz-2424R KCNH1/EAG1 钾离子通道蛋白EAG1抗体
hz-5123R Anterior Gradient 2 前梯度同源蛋白2抗体
hz-1815R HERG/KCNH2/ERG 特异性钾离子通道蛋白抗体
hz-2713R HAVCR1/TIM1 肾损伤分子1抗体（甲型肝炎病毒细胞受体1）
hz-0843R HA tag HA tag标签抗体
hz-0966R HA tag HA tag标签抗体
hzm-0966M HA tag(12CA5) HA tag标签单克隆抗体
hz-0540R HAI-1 肝细胞生长因子激活物抑制剂抗体
hz-1557G HBsAg 人乙肝表面抗原抗体（包被）
hz-0847R HBA1/Alpha globin/Hhzoglobin 血红蛋白α1抗体
hzm-2118M hHb(H5A3) 人血红蛋白单克隆抗体
hzm-2024M HBsAg(H2F4) 人乙型肝炎表面抗原单克隆抗体（检测）
hzm-2000M HBcAg(1H8) 人乙型肝炎核心抗原单克隆抗体
hzm-2022M HBeAg(2E9) 人乙型肝炎e抗原单克隆抗体（1）
hzm-2023M HBeAg(2E6) 人乙型肝炎e抗原单克隆抗体（2）
hz-2169R VWCE VWCE抗体
hz-2170R VWCE VWCE抗体
hz-3576R HB EGF/DTSF 肝素结合性表皮生长因子抗体
hz-2171R URG4 上调基因4抗体(N端)
hz-2172R URG4 (C terminal) 上调基因4抗体（C端）
hz-0343R large S protein 人乙肝病毒pre S1/S2蛋白抗体
hz-2327R HBV pre S1/S2 protein 人乙肝病毒pre S1/S2蛋白抗体
hz-2328R HBV pre S1/S2 protein 人乙肝病毒pre S1/S2蛋白抗体
hzm-2027M HCG Beta(4H7) 人绒毛膜促性腺激素β亚基单抗
hz-0402R HCCR1/BRI3BP 宫颈癌原基因1/bri3结合蛋白抗体
hz-5937R HCCR2/LETMD1 宫颈癌原癌基因2抗体
hzm-2026M HCG alpha(4A8) 人绒毛膜促性腺激素α 亚基单抗
hz-0953R Beta-HCG/HCG beta 人β亚基人绒毛膜促性腺激素(β HCG)抗体
hz-1912R HCG/LH/FSH/TSH alpha 人绒毛膜促性腺激素α亚基抗体(Cg A)
hz-1438R Hck 造血细胞激酶抗体
hz-1745R Factor H 补体因子H抗体
hz-5157R FHL2 相互作用蛋白FHL2抗体
hz-1691R HCN4 环化核苷酸调控阳离子通道蛋白亚型4
hz-5109R HCLS1/LckBP1 造血干细胞特异性蛋白抗体
hz-0221R HCV-Core protein 丙型肝炎病毒-C区抗体
hz-0728R ACY 3/HCV-HCBP1 丙型肝炎病毒核结合蛋白-1抗体
hz-0218R HCV-NS1 丙型肝炎病毒-NS1抗体
hz-0219R HCV-NS3 丙型肝炎病毒-NS3抗体