英文名称 RAB3GAP1
中文名称 RAB3-GTP酶激活蛋白催化亚单位1抗体
别 名 DKFZp434A012; KIAA0066; P130; Rab3 GAP; Rab3 GAP p130; RAB3 GTPase activating protein 130 kDa subunit; Rab3 GTPase activating protein catalytic subunit; RAB3GAP; RAB3GAP130; WARBM1; RB3GP_HUMAN.
RAB3-GTP酶激活蛋白催化亚单位1抗体
说 明 书 0.2ml
研究领域 细胞生物 发育生物学 神经生物学 G蛋白信号
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 110kDa
细胞定位 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human RAB3GAP1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
RAB3-GTP酶激活蛋白催化亚单位1抗体产品介绍 background:
Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab 3 GAP p130, also known as Rab3 GTPase-activating protein catalytic subunit, is a 981 amino acid protein that belongs to the Rab3-GAP catalytic subunit family. Rab 3 GAP p130 converts active RAB3-GTP to the inactive form RAB3-GDP, and is required for normal eye and brain development. Defects in Rab 3 GAP p130 are the cause of Warburg micro syndrome 1 (WARBM1). WARBM1 is a severe autosomal recessive disorder characterized by developmental abnormalities of the eye and central nervous system and by microgenitalia. The Rab 3 GAP p130 protein may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. Existing as two alternatively spliced isoforms, the Rab 3 GAP p130 gene is conserved in chimpanzee, dog, cow, mouse, chicken, zebrafish and fruit fly, and maps to human chromosome 2q21.3.
Function:
RAB3GAP1 is a member of the RAB3 protein family which are implicated in regulated exocytosis of neurotransmitters and hormones. RAB3GAP, which is involved in regulation of RAB3 activity, is a heterodimeric complex consisting a 130-kD catalytic subunit and a 150-kD noncatalytic subunit. RAB3GAP specifically converts active RAB3-GTP to the inactive form RAB3-GDP (Aligianis et al., 2005 [PubMed 15696165].
Subunit:
The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2
Subcellular Location:
Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.
Tissue Specificity:
Ubiquitous.
DISEASE:
Defects in RAB3GAP1 are the cause of Warburg micro syndrome type 1 (WARBM1) [MIM:600118]. A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism.
Similarity:
Belongs to the Rab3-GAP catalytic subunit family.
Gene ID:
22930
Database links:
Entrez Gene: 22930 Human
Omim: 602536 Human
SwissProt: Q15042 Human
Unigene: 306327 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
RAB3-GTP酶激活蛋白催化亚单位1抗体
hz-0607P OAT-1 (Organic anion transporter 1)mouse、rat 阴离子转运蛋白-1(大、小鼠同源:人源见bs-0606P)
hz-0609P OAT-3(Organic anion transporter 3) 阴离子转运蛋白-3(抗原)
hz-0604P galectin 9 半乳糖凝集素9(抗原)
hz-0830P Oct-4 胚胎干细胞关键蛋白(多肽)
hz-0026P OPN(osteopontin) 骨桥蛋白(抗原)
hz-0740P P16/CDKN2A (Cyclin-dependent kinase inhibitor-2A) 抑癌基因p16(抗原)
hz-0741P p21/WAF1/CIP1 p21 核分裂抑制因子之一(抗原)
hz-0742P p27 (cyclin-dependent kinase inhibitor 1B) p27(抗原)
hz-0723P P63 protein P63 肿瘤抑制基因(抗原)
hz-0431P OPG(Osteoprotegerin) 护骨素(多肽抗原)
hz-0747P OPGL (Osteoprotegerin ligand) 骨保护蛋白配体(抗原)
hz-0427P P311 protein 增生性瘢痕相关蛋白(抗原)
hz-0769P PARP(poly ADP-ribose polymerase) 多腺苷二磷酸多聚酶抗原
hz-0270P Visfatin-1 (PBEF1)(NT) Human 内脂素/内脏脂肪素(人:N端多肽)、内脏脂肪素、 又称:前B细胞克隆增强因子、内肥素、腹脂素
hz-0272P Visfatin-1 (PBEF1)(NT) 内脂素/内脏脂肪素
hz-0273P PBEF (CT) 内脂素/B细胞克隆增强因子
hz-0731P PEDF (pigment epithelium-derived factor) 色素上皮源性因子(多肽抗原)
hz-0739P PAP2c (Phosphatidic acid phosphatase 2c) 磷脂酸磷酸酶2C(抗原)
hz-0689P PEPT1 (Peptide-transporters 1) 肠道肽转运蛋白(小肽转运蛋白)多肽
hz-0748P PTEN/MMAC1 一种肿瘤抑制基因抗原
hz-0420P PIBF(progesterone induced blocking factor) 孕激素诱导阻断因子(抗原)
hz-0665P PIWIL1(piwi-like 1) piwi 样1蛋白(抗原)
hz-0530P PPAR Gamma (peroxisome proliferator-activated receptor-gamma) 过氧化酶活化增生受体γ(抗原)
hz-0490P PP2Ac 蛋白磷酸酶4(抗原)
hz-0378P Runx3 一种新发现的抑癌基因(抗原)
hz-0278P RRAD (Ras-related associated with diabetes ) RRAD(多肽抗原)
hz-0783P SDF-1/CXCL12 (stromal cell derived factor-1) 基质细胞衍生因子-1(抗原)
hz-0211P shank1(SH3 and multiple anleyrin repead domins protein 1) shank1多肽抗原
hz-0444P slc22A17 (solute carrier famili 22) 溶质转运蛋白家族22成员17(多肽抗原)
hz-0496P SLC24A5 (solute carrier family 24, mhzber 5) 可溶性载质转运蛋白SLC24A5(抗原)
hz-0473P solute carrier family 1 溶质携带物家族-1(抗原)
hz-0478P SLC6A4 (solute carrier family 6) 钾依赖钠钙交换蛋白6(抗原)
hz-0615P Survivin 细胞凋亡抑制因子的一种(抗原)
hz-0726P BIRC5/Survivin variant 细胞凋亡抑制因子4(抗原)
RAB3-GTP酶激活蛋白催化亚单位1抗体多少钱?
R&D抗体/抗原的应用资料有吗?
R&D抗体/抗原货号hz-11938R报价含票含运吗?
R&D货号hz-11938R货期是多久?
沪震实业RAB3-GTP酶激活蛋白催化亚单位1抗体可以申请试用吗?
沪震实业R&D抗体/抗原售后政策是什么?
RAB3-GTP酶激活蛋白催化亚单位1抗体有现货吗?