维甲酸诱导蛋白3抗体

英文名称    RAI3    

中文名称    维甲酸诱导蛋白3抗体    

别    名    G protein coupled receptor family C group 5 member A; G-protein coupled receptor family C group 5 member A; GPCR 5A; GPCR5A; Gprc 5a; Gprc5a; Orphan G protein coupling receptor PEIG 1; Orphan G protein coupling receptor PEIG1; Orphan G-protein-coupling receptor PEIG-1; RAI 3; RAI3_HUMAN; Raig 1; RAIG-1; Raig1; Retinoic acid induced 3; Retinoic acid induced gene 1 protein; Retinoic acid induced protein 3; Retinoic acid responsive; Retinoic acid responsive gene; Retinoic acid-induced gene 1 protein; Retinoic acid-induced protein 3.    

维甲酸诱导蛋白3抗体      

说 明 书    0.2ml      

研究领域    肿瘤  神经生物学  信号转导  细胞凋亡  G蛋白偶联受体  细胞分化  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human,     

产品应用    ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    40kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RAI3 (1-33aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

维甲酸诱导蛋白3抗体产品介绍    background:
RAI3 is an transmembrane G-protein-coupled receptor that affects many essential biological processes including embryogenesis, cell growth, differentiation, and apoptosis. RAI3 may also be involved in maintaining homeostasis of epithelial cells. Retinoic acid receptors directly regulate RAI3 during its transcription in embryonal carcinoma differentiation. RAI3 expression is upregulated in most tumor cell lines that express mutant p53, suggesting that p53 interacts with the promoter of RAI3 and represses its expression at the beginning of apoptosis. RAI3 is a potential molecular target for diagnosing breast cancer, and selective suppression of signals from RAI3 may have a place in breast cancer treatments.

Function:
Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

Subcellular Location:
Cell membrane. Cytoplasmic vesicle membrane. Localized in the plasma membrane and perinuclear vesicles.

Tissue Specificity:
Expressed at high level in fetal and adult lung tissues. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart.

Similarity:
Belongs to the G-protein coupled receptor 3 family.

Database links:
UniProtKB/Swiss-Prot: Q8NFJ5.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

维甲酸诱导蛋白3抗体

hz-1186P CD36L1/SRB1 peptide  高密度脂蛋白受体/清道夫受体抗原

hz-2155P HER2 receptor(NT)(erbB-2 isoform 2 receptor N-Terminus)  c-erbB-2受体抗体(N端)

hz-2156P HER2 receptor(NT)(erbB-2 isoform 2 receptor N-Terminus)  c-erbB-2受体抗原(N端)

hz-1025P HGF(hepatocyte growth factor)  肝细胞生长因子抗原

hz-0860P HHV8/ORF50(Human herpesvirus 8 type P)  人类疱疹病毒8抗原

hz-0859P HHV8/ORF50(Human herpesvirus 8 type P)  人类疱疹病毒8抗原

hz-0870P HHV8/ORF K2(Human herpesvirus 8 type P)  人类疱疹病毒8抗原

hz-1407P HIF-1 Beta/ARNT1(Hypoxia-inducible factor-1 Beta)  缺氧诱导因子1β 抗原

hz-1447P HIF-2 Alpha (Hypoxia-inducible factor-2 Alpha)  缺氧诱导因子2α 抗原

hz-0931P Histone H1b(Histone H1.4)  组蛋白H1b抗原

hz-1414P HDAC1/HD1(histone deacetylase 1)  组织蛋白去乙酰化酶1抗原

hz-0879P Flag-Tag (CT)  Flag Tag标签多肽

hz-0965P DYKDDDDK Tag(CT)/Flag-Tag  标签DYKDDDDK Tag分支肽

hz-2107P T7 tag(recombinant T7-tagged proteins)  T7 tag标签抗原

hz-2109P V5 tag(recombinant V5-tagged protein)  V5 tag多肽抗原

hz-2112P KT3 tag  KT3 tag标签抗原

hz-2110P VSV-G tag(vesicular stomatitis virus glycoprotein)  VSV-G tag标签抗原

hz-1198P HLA-DR(human leukoyte Antigen DR)  HLA-DR抗原

hz-1279P HLA-E  人类白细胞抗原E

hz-1030P Anti-HMGA1 (high mobility group AT-hook 1)  高迁移率族蛋白A1抗原

hz-0556P HMGA2 (high mobility group A2)  高迁移率族蛋白A2抗原

hz-0827P HO-1/HSP32 (Hhzeo xygenase 1)  血红素氧合酶-1/热休克蛋白-32抗原

hz-2075P HO-1/HSP32(Hhzeo xygenase 1)  血红素氧合酶-1/热休克蛋白-32抗原

hz-1238P HO-2(Hhze oxygenase 2)  血红素氧合酶-2抗原

hz-0928P phospho-HP1/heterochromatin protein 1 (pTyr24)(fruit fly)  异染色质蛋白1(磷酸化多肽)

hz-0930P phospho-heterochromatin protein 1 (pTyr41)peptide  异染色质蛋白1（磷酸化多肽）

hz-0990P HPV16-E6/E6 protein(Human papillomavirus type 16)  人类乳头状瘤病毒16抗原

hz-0991P HPV18 E6  人类乳头状瘤病毒18E6

hz-0992P HPV16-E7/E7 protein(Human papillomavirus type 16)  人类乳头状瘤病毒16抗原

hz-1808P Hpt/HP(haptoglobin)  结合珠蛋白/触珠蛋白抗原

hz-1071P H-ras/Ras/Ras p21 peptide  原癌基因H-ras抗原

hz-1409P HSTF2/HSF2 peptide  热休克转录因子2抗原

hz-0662P BCRP/ABCG2(breast cancer resistance protein)  乳腺癌耐药相关蛋白（抗原）

hz-2145P Hrasls3/HREV107(HRAS like suppressor 3)  HRAS样抑制因子3抗原

hz-1538P HSP47(Heat shock protein-47)  热休克蛋白-47抗原

hz-0889P HSP-90 Alpha(Heat Shock Protein 90 Alpha )  热休克蛋白90α抗体