Runx3抗体

英文名称    Runx3    

中文名称    Runx3抗体    

别    名    RUNX 3; RUNX-3; Runt-related transcription factor 3; Core-binding factor, alpha 3 subunit; CBF-alpha 3; Acute myeloid leukemia 2 protein; OncogeneAML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEBP2-alpha C; PEA2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; Core-binding factor, alpha 3 subunit; CBF-alpha 3; Acute myeloid leukemia 2 protein; Oncogene AML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEBP2-alpha C; PEA2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit.    

Runx3抗体        

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  转运蛋白  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    47kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Runx3    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

Runx3抗体产品介绍    background:
RUNX3 binds to the core site of murine Leukemia virus, the core sequences in the enhancer of the polyomavirus, and also to the enhancers of the T-cell receptor genes. May be involved in the control of cellular proliferation and/or differentiation (By similarity). Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain.DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1, Subcellular location in Nucleus. 

Function:
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.

Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK.

Subcellular Location:
Nucleus. Cytoplasm. The tyrosine phosphorylated form localizes to the cytoplasm.

Post-translational modifications:
Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN.

Similarity:
Contains 1 Runt domain.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

Runx3抗体

hz-4002P phospho-AMPK alpha 1(Thr172) peptaide  磷酸化腺苷单磷酸活化蛋白激酶α1抗原

hz-0049P Caspase-9  白介素1-β转化酶样凋亡蛋白酶6（抗原）

hz-0050P Caspase-9   白介素1-β转化酶样凋亡蛋白酶6（抗原）

hz-2105P AD7C-NTP/NTP/AF peptide   神经丝蛋白蛋白多肽抗原（人）

hz-0092P Caspase-10   半胱胺酸蛋白酶-10（抗原）

hz-0053P Caspase-13   半胱胺酸蛋白酶蛋白-13（抗原）

hz-0079P CD19(B-lymphocyte antigen CD19)  CD19

hz-4532PB Clenbuterol Hydrochloride/BSA  盐酸克仑特罗偶联牛血清白蛋白BSA

hz-4532PK Clenbuterol Hydrochloride/KLH  盐酸克仑特罗偶联血蓝蛋白KLH

hz-4533PB Estradiol/BSA  雌二醇偶联牛血清白蛋白

hz-2167P DRADA/ADAR1(Double-stranded RNA-specific adenosine deaminase)N terminal  双链RNA腺苷酸脱氨基酶抗原（N端）

hz-2168P DRADA/ADAR1(Double-stranded RNA-specific adenosine deaminase)  双链RNA腺苷酸脱氨基酶抗原

hz-4545PB Ractopamine/BSA  莱克多巴胺与牛血清白蛋白偶联物

hz-4545PK Ractopamine/KLH  莱克多巴胺与血蓝蛋白偶联物

hz-4593P MMP9  基质金属蛋白酶9

hz-4609P CD105/Endoglin  CD105蛋白

hz-4622P Mycobacterium bovis   牛结核杆菌菌体蛋白

hz-4687P AMH/MIS  Muellerian抑制因子抗原

hz-2231P AEG-1 peptide  AEG-1抗原

hz-0195P CD31 (PECAM-1)  血小板内皮细胞黏附分子-1（抗原）

hz-1164P ADFP/ADRP/adipophilin   脂肪组织分化相关蛋白抗原

hz-0298P Immunoglobuin binding protein-1(CD79A)IGBP-1  免疫球蛋白结合蛋白-1

hz-4770P CD133  造血干细胞抗原CD133

hz-0209P CD133  造血干细胞抗原（多肽抗原）

hz-4813P H5N1-H5  禽流感H5亚型全病毒

hz-4814P Newcastle disease virus  鸡新城疫疫苗（鸡瘟4型混合病毒）

hz-4938P SDF-1/CXCL12  基质细胞衍生因子1

hz-4948P Bacillus anthraci  炭疽杆菌菌体蛋白

hz-3681P ADCY1 peptide  腺苷酸环化酶1多肽抗原

hz-0125P c-erbB-2蛋白  c-erbB-2蛋白（抗原）

hz-0042P ChAT(Choline Acetyltransferase)  胆碱乙酰转移酶（抗原）

hz-5109P HCLS1  造血干细胞特异性蛋白

hz-0236P ChRM2 (Muscarinic Acetylcholine receptor M2)  毒蕈碱型乙酰胆碱受体（抗原）

hz-0274P C-Peptide( C-PEP )  C-肽（C肽）

hz-0062P CR (Calretinin)  钙结合蛋白（抗原）

hz-0155P CRP (C-reactive protin)  C-反应蛋白（抗原）

hz-1225P ADORA3/A3AR(adenosine receptor A3)  腺苷受体A3抗原