轴突导向受体蛋白3抗体

英文名称    Robo3    

中文名称    轴突导向受体蛋白3抗体    

别    名    HGPPS; HGPS; RB inhibiting gene 1; Rbig 1; Rbig1; Retinoblastoma inhibiting gene 1; Rig 1; Rig1; Robo 3; Robo3; Robo3 protein; ROBO3_HUMAN; Roundabout axon guidance receptor homolog 3; Roundabout homolog 3; Roundabout like protein 3; Roundabout, axon guidance receptor, homolog 3 (Drosophila); Roundabout-like protein 3.    

轴突导向受体蛋白3抗体         

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  神经生物学  细胞膜受体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    146kDa    

细胞定位    细胞膜 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Robo3    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

轴突导向受体蛋白3抗体 产品介绍    background:
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.

Function:
Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing.

Subcellular Location:
Membrane; Single-pass type I membrane protein

DISEASE:
Defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis (HGPPS) [MIM:607313]. Patients show a medulla where motor and sensory projections appear uncrossed.

Similarity:
Belongs to the immunoglobulin superfamily. ROBO family. 
Contains 3 fibronectin type-III domains. 
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Gene ID:
64221

Database links:

Entrez Gene: 489307 Dog

Entrez Gene: 100072287 Horse

Entrez Gene: 64221 Human

Entrez Gene: 19649 Mouse

Entrez Gene: 30770 Zebrafish

Omim: 608630 Human

SwissProt: Q96MS0 Human

SwissProt: Q9Z2I4 Mouse

Unigene: 435621 Human

Unigene: 212826 Mouse

Entrez Gene: 712 Human

Entrez Gene: 713 Human

Entrez Gene: 714 Human

Entrez Gene: 12259 Mouse

Entrez Gene: 12260 Mouse

Entrez Gene: 12262 Mouse

Entrez Gene: 29687 Rat

Entrez Gene: 298566 Rat

Entrez Gene: 362634 Rat

Omim: 120550 Human

Omim: 120570 Human

Omim: 120575 Human

SwissProt: P02745 Human

SwissProt: P02746 Human

SwissProt: P02747 Human

SwissProt: P14106 Mouse

SwissProt: P98086 Mouse

SwissProt: Q02105 Mouse

SwissProt: P31720 Rat

SwissProt: P31721 Rat

SwissProt: P31722 Rat

Unigene: 632379 Human

Unigene: 439957 Mouse

Unigene: 105647 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

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