纤溶酶原激活物抑制因子2/血浆酶原激活酶抑制因子-2抗体

英文名称    SerpinB2    

中文名称    纤溶酶原激活物抑制因子2/血浆酶原激活酶抑制因子-2抗体    

别    名    Serpin B2; Serpinb2; SerpinB2; plasminogen activator inhibitor 2; HsT1201; Monocyte Arg serpin; Monocyte Arg-serpin; PAI2A; PAI; PAI-2; PAI 2; PAI2; Placental plasminogen activator inhibitor; PAI2_RAT; PLANH2; Plasminogen activator inhibitor 2; Plasminogen activator inhibitor 2 type A; Serpin peptidase inhibitor clade B (ovalbumin) member 2; Urokinase inhibitor.    

纤溶酶原激活物抑制因子2/血浆酶原激活酶抑制因子-2抗体        

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  泛素      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    47kDa    

细胞定位    细胞浆 细胞外基质 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PAI-2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

纤溶酶原激活物抑制因子2/血浆酶原激活酶抑制因子-2抗体产品介绍    background:
SerpinB2 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in the placenta, and given the name PAI-2 because of the ability to inhibit urokinase plasminogen activator (u-PA) at low micromolar efficiency. SerpinB2 also inhibits tissue plasminogen activator (t-PA), but with micromolar efficiency, and PAI-1 is much more efficient that SerpinB2 on both forms of plasminogen activator. The structure of PAI-2 is not terribly similar to PAI-1, however, which is an E clade serpin.
SerpinB2 is made by many cell types, and is found intracellularly as an unglycosylated kDa protein, and secreted as a 60 kDa protein. SerpinB2 is found in saliva, secreted by gingival fibroblasts, and in the skin. SerpinB2 levels are elevated in serum during pregnancy, and in leukemia, breast cancer and ovarian cancer, although it was lowered in some cancers.A shorter SerpinB2 isoform of 382 amino acids, has been reported, with a predicted mass of 43.1 kDa and a pI of 5.69. The shorter form has a deletion just after the start of the mature protein, but it is unclear what the relative production and distribution is for the shorter sequence.

Function:
Inhibits urokinase-type plasminogen activator.

Subunit:
Interacts with PSMB1.

Subcellular Location:
Cytoplasm. Secreted, extracellular space.

Post-translational modifications:
The signal sequence is not cleaved.

Similarity:
Belongs to the serpin family. Ov-serpin subfamily.

Gene ID:
5055

Database links:

Entrez Gene: 5055 Human

Entrez Gene: 18788 Mouse

Omim: 173390 Human

SwissProt: P05120 Human

SwissProt: P12388 Mouse

Unigene: 594481 Human

Unigene: 271870 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

纤溶酶原激活物抑制因子2/血浆酶原激活酶抑制因子-2抗体

hz-0314R-Gold Rabbit Anti-chicken IgM/Gold  胶体金标记的兔抗鸡IgM

hz-0314R-RBIThz Rabbit Anti-chicken IgM/RBITC  罗丹明标记的兔抗鸡IgM

hz-0314R-hzy3 Rabbit Anti-chicken IgM/Cy3  Cy3标记的兔抗鸡IgM

hz-0314R-hzy5 Rabbit Anti-chicken IgM/Cy5  Cy5标记的兔抗鸡IgM

hz-0314R-hzy5.5 Rabbit Anti-chicken IgM/Cy5.5  Cy5.5标记的兔抗鸡IgM

hz-0314R-hzy7 Rabbit Anti-chicken IgM/Cy7  Cy7标记的兔抗鸡IgM

hz-0314R-PE Rabbit Anti-chicken IgM/PE  PE标记的兔抗鸡IgM

hz-0314R-PE-hzy3 Rabbit Anti-chicken IgM/PE-Cy3  PE-Cy3标记的兔抗鸡IgM

hz-0314R-PE-hzY5 Rabbit Anti-chicken IgM/PE-CY5  PE-CY5标记的兔抗鸡IgM

hz-0314R-APhz Rabbit Anti-chicken IgM/APC  APC标记的兔抗鸡IgM

hz-0314R-HRP Rabbit Anti-chicken IgM/HRP  辣根过氧化物酶标记的兔抗鸡IgM

hz-0314R-AP Rabbit Anti-chicken IgM/AP  碱性磷酸酶（AP）标记的兔抗鸡IgM

hz-0314R-AF350 Rabbit Anti-chicken IgM/Alexa Fluor 350  Alexa Fluor 350标记的兔抗鸡IgM

hz-0314R-AF488 Rabbit Anti-chicken IgM/Alexa Fluor 488  Alexa Fluor 488标记的兔抗鸡IgM

hz-0314R-AF555 Rabbit Anti-chicken IgM/Alexa Fluor 555  Alexa Fluor 555标记的兔抗鸡IgM

hz-0314R-AF647 Rabbit Anti-chicken IgM/Alexa Fluor 647  Alexa Fluor 647标记的兔抗鸡IgM

hz-0314R-PE-hzy5.5 Rabbit Anti-chicken IgM/PE-Cy5.5  PE-Cy5.5标记的兔抗鸡IgM

hz-0314R-PE-hzy7 Rabbit Anti-chicken IgM/PE-Cy7  PE-Cy7标记的兔抗鸡IgM

hz-0314R-Bio Rabbit Anti-chicken IgM/Bio  生物素标记的兔抗鸡IgM

hz-0303R-Bio Rabbit Anti-dog IgG/Bio  生物素标记的兔抗狗IgG

hz-0303R-HRP Rabbit Anti-dog IgG/HRP  辣根过氧化物酶标记的兔抗狗IgG

hz-0303R-AP Rabbit Anti-dog IgG/AP  碱性磷酸酶（AP）标记的兔抗狗IgG

hz-0303R-hzy3 Rabbit Anti-dog IgG/Cy3  Cy3标记的兔抗狗IgG

hz-0303R-hzy5 Rabbit Anti-dog IgG/Cy5  Cy5标记的兔抗狗IgG

hz-0303R-hzy5.5 Rabbit Anti-dog IgG/Cy5.5  Cy5.5标记的兔抗狗IgG

hz-0303R-hzy7 Rabbit Anti-dog IgG/Cy7  Cy7标记的兔抗狗IgG

hz-0303R-PE Rabbit Anti-dog IgG/PE  PE标记的兔抗狗IgG

hz-0303R-PE-hzy3 Rabbit Anti-dog IgG/PE-Cy3  PE-Cy3标记的兔抗狗IgG

hz-0303R-PE-hzY5 Rabbit Anti-dog IgG/PE-CY5  PE-CY5标记的兔抗狗IgG

hz-0303R-APhz Rabbit Anti-dog IgG/APC  APC标记的兔抗狗IgG

hz-0303R-AF350 Rabbit Anti-dog IgG/Alexa Fluor 350  Alexa Fluor 350标记的兔抗狗IgG

hz-0303R-AF647 Rabbit Anti-dog IgG/Alexa Fluor 647  Alexa Fluor 647标记的兔抗狗IgG

hz-0303R-PE-hzy5.5 Rabbit Anti-dog IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗狗IgG

hz-0303R-PE-hzy7 Rabbit Anti-dog IgG/PE-Cy7  PE-Cy7标记的兔抗狗IgG

hz-0303R-RBIThz Rabbit Anti-dog IgG/RBITC  罗丹明标记的兔抗狗IgG

hz-0303R-Gold Rabbit Anti-dog IgG/Gold  胶体金标记的兔抗狗IgG

hz-0303R-FIThz Rabbit Anti-dog IgG/FITC  FITC标记的兔抗狗IgG

hz-0303R-AF488 Rabbit Anti-dog IgG/Alexa Fluor 488  Alexa Fluor 488标记的兔抗狗IgG

hz-0303R-AF555 Rabbit Anti-dog IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗狗IgG

hz-0294R-PE-hzY5 Rabbit Anti-Goat IgG/PE-CY5  PE-CY5标记的兔抗羊IgG

hz-0294R-APhz Rabbit Anti-Goat IgG/APC  APC标记的兔抗羊IgG