英文名称 SFTPD
中文名称 肺表面活性蛋白D抗体
别 名 SFTPD surfactant protein D; pulmonary surfactant-associated glycoprotein D; COLEC 7; COLEC7; Collectin7; PSP D; PSPD; Pulmonary surfactant apoprotein; Pulmonary surfactant associated protein D; SFTP 4; SFTP4; SFTPD; SP D; Surfactant associated protein pulmonary 4; Surfactant pulmonary associated protein D; SFTPD_HUMAN; Pulmonary surfactant-associated protein D; PSP-D; SP-D; Collectin-7; Lung surfactant protein D.
肺表面活性蛋白D抗体
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 免疫学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SP-D
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
肺表面活性蛋白D抗体产品介绍 background:
Surfactant protein D contributes to the lung's defense against inhaled microorganisms. It's a calcium ion dependent carbohydrate binding protein and is structurally similar to other C type mammalian lectins, such as conglutinin and SPA. It has a molecular size of approximately 37-43kDa in its reduced state, 620kDa in non dissociating conditions. Surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages and regulates some actions of SPA, which is the most abundant surfactant protein. Surfactant protein D is synthesized and secreted by alveolar epithelial type II cells.
Function:
Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
Subunit:
Oligomeric complex of 4 set of homotrimers.
Subcellular Location:
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
Post-translational modifications:
The N-terminus is blocked.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
Similarity:
Belongs to the SFTPD family.
Contains 1 C-type lectin domain.
Contains 1 collagen-like domain.
Gene ID:
6441
Database links:
Entrez Gene: 6441 Human
Entrez Gene: 20390 Mouse
Entrez Gene: 25350 Rat
Omim: 178635 Human
SwissProt: P35247 Human
SwissProt: P50404 Mouse
SwissProt: P35248 Rat
Unigene: 253495 Human
Unigene: 1321 Mouse
Unigene: 11348 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肺表面活性蛋白D抗体
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