突触结合蛋白14抗体

英文名称    Synaptotagmin-14    

中文名称    突触结合蛋白14抗体    

别    名    Synaptotagmin14; Synaptotagmin 14; SCAR11; Synaptotagmin XIV; Synaptotagmin-14; SYT14; SYT14_HUMAN; SytXIV.    

突触结合蛋白14抗体      

说 明 书    0.2ml      

研究领域    细胞生物  神经生物学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

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 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    62

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kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Synaptotagmin-14 (477-555aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

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保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

突触结合蛋白14抗体产品介绍    background:
Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Synaptotagmin XIV, also known as SytXIV, is a 555 amino acid single-pass type III membrane protein belonging to the Synaptotagmin family. With the ability to form heterodimers, Synaptotagmin XIV mainly exists as a homodimer and contains two C2 domains, an N-terminal transmembrane domain and a putative fatty-acylation site. Synaptotagmin XIV is Ca2+-independent and may function in the trafficking and exocytosis of secretory vesicles to tissues outside the brain. Disruption of Synaptotagmin XIV may be affiliated with neurodevelopmental abnormalities. Synaptotagmin XIV exists as six alternatively spliced isoforms and is encoded by a gene on human chromosome 1q32.2.

Function:
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.

Subunit:
Homodimer. Can also form heterodimers

Subcellular Location:
Membrane; Single-pass type III membraneprotein. Note=Localized in perinuclear and submembranous regions.

Tissue Specificity:
Highly expressed in fetal and adult braintissue.

DISEASE:
Defects in SYT14 are the cause of spinocerebellar ataxiaautosomal recessive type 11 (SCAR11) [MIM:614229]. Spinocerebellarataxia is a clinically and genetically heterogeneous group ofcerebellar disorders. Patients show progressive incoordination ofgait and often poor coordination of hands, speech and eyemovements, due to degeneration of the cerebellum with variableinvolvement of the brainstem and spinal cord. SCAR11 is associatedwith psychomotor retardation.

Similarity:
Belongs to the synaptotagmin family. Contains 2 C2 domains.

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Database links:
UniProtKB/Swiss-Prot: Q8NB59.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

突触结合蛋白14抗体

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