泛素样蛋白Sumo2/3抗体

英文名称    Sumo 2+3    

中文名称    泛素样蛋白Sumo2/3抗体    

别    名    HSMT3; MGC117191; OTTHUMP00000115275; OTTHUMP00000115276; OTTHUMP00000115277; Sentrin 2; Small ubiquitin like modifier 2; Small ubiquitin like modifier protein 3; Small ubiquitin related modifier 2; Small ubiquitin related modifier 3; SMT3 A; SMT3 B; SMT3 H1; SMT3 H2; SMT3 homolog 1; SMT3 homolog 2; SMT3 homolog; SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); SMT3 suppressor of mif two 3 homolog 2; SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae); SMT3 suppressor of mif two 3 homolog 3; SMT3A; SMT3B; SMT3H1; SMT3H2; Sumo 2; Sumo 3; Sumo2; Sumo3; Suppressor of mif two 3 homolog 2; Suppressor of mif two 3 homolog 3; Ubiquitin like protein SMT3A; Ubiquitin like protein SMT3B; SUMO2_HUMAN; SUMO3_HUMAN.    

泛素样蛋白Sumo2/3抗体      

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  神经生物学  细胞周期蛋白  泛素      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Zebrafish,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    10.9+10.5kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Sumo 2+3    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 泛素样蛋白Sumo2/3抗体  产品介绍    background:
The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease.

Function:
SUMO proteins, such as Sumo 2 and Sumo 3, post-translationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. Sumo 2 and Sumo 3 are highly homologous, hence it is very difficult to produce antibodies which distinguish them.

Subunit:
Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains).

Subcellular Location:
Cytoplasmic (SUMO3) and Nuclear (SUMO2)

Tissue Specificity:
Broadly expressed.

Post-translational modifications:
Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4. 
Cleavage of precursor form by SENP1 or SENP2 is necessary for function.

Similarity:
Belongs to the ubiquitin family. SUMO subfamily. 
Contains 1 ubiquitin-like domain. 

Database links:
UniProtKB/Swiss-Prot: P61956.3 UniProtKB/Swiss-Prot: P55854.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

泛素样蛋白Sumo2/3抗体  

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hz-2589R P450 1A2/CYP1A2  细胞色素P450 1A2抗体

hz-3608R CYP11A1/P450SCC  细胞色素P450 11A1抗体

hz-2887R CYP2C9  细胞色素P450 2C9抗体

hz-3898R CYP11B1  细胞色素P450 11B1抗体

hz-4108R Cytochrome P450 2D1  细胞色素CYP2D1抗体

hz-1742R CYP3A4  细胞色素P450 3A4抗体

hz-2375R CYP3A1  细胞色素P450 3A1抗体

hz-5054R CYP4A1  细胞色素P450 4A1抗体

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hz-2399R CYP7A1  细胞色素P450 7A1抗体/胆固醇7a羟化酶

hz-2991R CYP2D6  细胞色素P450 2D6抗体

hz-2352R Cytochrome P450 2B6  细胞色素P450 2B6抗体

hz-3853R CYP17  细胞色素P450 17抗体

hz-1292R CYP19/CYP19A1  细胞色素P450 19抗体

hz-5052R CYP7B1  胆固醇25α7羟化酶抗体

hz-3677R CYP8A1/PTGIS  前列环素合成酶抗体

hz-2443R CYP21  胆固醇21-羟化酶抗体

hz-2795R CYP2C19  细胞色素P450 2C19抗体

hz-3899R CYP24A1  细胞色素P450 24A1抗体

hz-5049R CYP27A1  胆固醇27α羟化酶抗体

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hz-1725R CYP2E1  细胞色素P450ⅡE1抗体

hz-4562R CYP2E1  细胞色素P450ⅡE1抗体

hz-3900R CYP2R1  细胞色素P450 2R1抗体

hz-5046R CYP46  胆固醇24S－羟化酶

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hz-5051R CYP46  胆固醇24羟化酶抗体