可溶性E选择素

英文名称    se-selectin    

中文名称    可溶性E选择素    

别    名    Endothelial leukocyte adhesion molecule 1; ELAM-1; Leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD62 antigen-like family member E; CD62E antigen; LYAM2_HUMAN.    

可溶性E选择素       

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  信号转导  细胞粘附分子  细胞表面分子  细胞类型标志物      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    65kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human se-selectin    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

可溶性E选择素产品介绍    background:
The se-selectin is expressed by cytokine-stimulated endothelial cells. It is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. This gene is present in single copy in the human genome and contains 14 exons spanning about 13 kb of DNA. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. 

Subunit:
Interacts with PSGL1/SELPLG through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the selectin/LECAM family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 6 Sushi (CCP/SCR) domains.

Gene ID:
6401

Database links:

Entrez Gene: 6401 Human

Entrez Gene: 20339 Mouse

Entrez Gene: 25544 Rat

Omim: 131210 Human

SwissProt: P16581 Human

SwissProt: Q00690 Mouse

SwissProt: P98105 Rat

Unigene: 82848 Human

Unigene: 5245 Mouse

Unigene: 10359 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

可溶性E选择素

hz-4294R Bub1  纺锤体检查点蛋白抗体

hz-1035R CD86/B7-2  CD86抗体

hz-2470R CD244  CD244抗体

hz-5284R phospho-CD244(Tyr271)  磷酸化CD244抗体

hz-2473R BLAME/SLAMF8  BLAME抗体

hz-1341R Cdc2/CDK1  周期素依赖激酶1抗体

hz-3091R Phospho-cdc2 (Thr14)  磷酸化周期素依赖激酶2抗体

hz-3092R Phospho-cdc2 (Tyr15)  磷酸化周期素依赖激酶2抗体

hz-3481R Phospho-cdc2 (Thr161)  磷酸化周期素依赖激酶2抗体

hz-5247R Phospho-cdc2 (Ser39)  磷酸化周期素依赖激酶2抗体

hz-2758R Cdc25A  细胞分裂周期蛋白25抗体

hz-3093R Phospho-cdc25A (Thr506)  磷酸化细胞分裂周期蛋白25抗体

hz-3094R Phospho-cdc25A (Ser76)  磷酸化细胞分裂周期蛋白25抗体

hz-3095R Phospho-cdc25A (Ser178)  磷酸化细胞分裂周期蛋白25抗体

hz-3096R Phospho-cdc25C (Ser216)  磷酸化细胞分裂周期蛋白25C抗体

hz-3482R Phospho-cdc25C (Thr48)  磷酸化细胞分裂周期蛋白25C抗体

hz-5242R Phospho-cdc25A (Ser124)  磷酸化细胞分裂周期蛋白25抗体

hz-5261R Phospho-cdc25A (Ser177)  磷酸化细胞分裂周期蛋白25抗体

hz-5262R Phospho-cdc25A (Ser292)  磷酸化细胞分裂周期蛋白25抗体

hz-2417R CD335/NKp46/NCR1  细胞毒性受体NK-p46抗体

hz-2420R CD336/NKp44/NCR2  细胞毒性受体NK-p44抗体

hz-2418R CD337/NKp30/NCR3  细胞毒性受体NK-p30抗体

hz-2466R CD328/Siglec-7  唾液酸结合性免疫球蛋白样凝集素7抗体

hz-4094R Cdc25B  细胞分裂周期蛋白25B抗体

hz-2705R CD329/SIGLEC8  CD329抗体

hz-5243R phospho-Cdc25B (Ser323)  磷酸化细胞分裂周期蛋白25B抗体

hz-5244R phospho-Cdc25B (Ser186)  磷酸化细胞分裂周期蛋白25B抗体

hz-2681R KLRF1/NKp80  细胞毒性受体NK-p80抗体

hz-5245R phospho-Cdc25B (Ser353)  磷酸化细胞分裂周期蛋白25B抗体

hz-2706R SIGLEC10/SLG2  唾液酸结合性免疫球蛋白样凝集素抗体

hz-1390R Cdc6  细胞分裂周期蛋白6抗体

hz-1448R Jagged1/CD339  Jagged1/CD339抗体

hz-5148R Cdc7  细胞分裂周期蛋白7抗体

hz-4244R Jagged 2  Notch配体Jagged 2蛋白抗体

hz-3525R SIGLEC14  唾液酸结合性免疫球蛋白样凝集素14抗体