钠离子通道相关蛋白1抗体

英文名称    SCLT1    

中文名称    钠离子通道相关蛋白1抗体    

别    名    CAP-1A; CAP1A; FLJ30655; hCAP-1A; SAP1; SCLT1; SCLT1_HUMAN; Sodium channel and clathrin linker 1; Sodium channel-associated protein 1.    

 钠离子通道相关蛋白1抗体        

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  神经生物学  信号转导  通道蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SCLT1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.    

 钠离子通道相关蛋白1抗体 产品介绍    background:
SCLT1 (sodium channel and clathrin linker 1), also known as CAP1A or hCAP-1A, is a 688 amino acid cytoplasmic protein that acts as a linker between the voltage-gated sodium channel, Na+ CP type X? and clathrin. SCLT1 is abundantly expressed in DRG (dorsal root ganglia) neurons and colocalizes with Na+ CP type X? SCLT1 regulates Na+ CP type X?channel activity by promoting channel internalization. SCLT1 exists as four alternatively spliced isoforms and is encoded by a gene located on human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.

Function:
Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization.

Subunit:
Interacts with SCN10A and clathrin. Identified in a complex containing SCN10A, clathrin and SCLT1 (By similarity).

Subcellular Location:
Cytoplasm. Cell periphery.

Database links:

Entrez Gene: 132320 Human

Omim: 611399 Human

SwissProt: Q96NL6 Human

Unigene: 654690 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

 钠离子通道相关蛋白1抗体 

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hz-0084M Caspase-6 (NT)  半胱胺酸蛋白酶蛋白-6抗体(N端)

hz-5240R phospho-Caspase 6 (Ser257)  磷酸化半胱胺酸蛋白酶蛋白6抗体

hz-3665R Caspase-7  半胱胺酸蛋白酶蛋白-7抗体

hz-2322R Caspase-7  半胱胺酸蛋白酶蛋白-7抗体

hz-0052R Caspase 8  半胱氨酸蛋白酶8抗体

hz-0049R Caspase-9  白介素1-β转化酶样凋亡蛋白酶6抗体

hz-0050R Caspase-9  白介素1-β转化酶样凋亡蛋白酶6抗体

hz-3082R Phospho-Caspase-9 (Thr125)  磷酸化半胱氨酸蛋白酶9抗体

hz-3083R Phospho-Caspase-9 (Tyr153)  磷酸化半胱氨酸蛋白酶9抗体

hz-5241R Phospho-Caspase-9 (Ser196)  磷酸化半胱氨酸蛋白酶9抗体

hz-1453R Caveolin-1  细胞质膜微囊蛋白-1抗体

hz-3480R Phospho-Caveolin-1 (Tyr14)  磷酸化细胞质膜微囊蛋白-1抗体

hz-3610R Caveolin-3  细胞质膜微囊蛋白-3抗体

hz-1594R Alpha-Catenin/CTNNA1  α-连环蛋白抗体（钙粘蛋白相关蛋白）

hz-5280R phospho-CTNNA1 (Ser641)  磷酸化α-连环蛋白抗体

hz-1165R β-catenin  β-连环蛋白/β-连环素/β链接素抗体

hz-2063R phospho-β catenin(Tyr142)  磷酸化β 连环素蛋白抗体

hz-3084R Phospho-Beta-Catenin(Ser33/37)  磷酸化β 连环素蛋白抗体

hz-3085R Phospho-Beta-Catenin(Ser45)  磷酸化β 连环素蛋白抗体

hz-3086R Phospho-Beta-Catenin (Ser552)  磷酸化β 连环素蛋白抗体

hz-3087R Phospho-Beta-Catenin (Ser675)  磷酸化β 连环素蛋白抗体

hz-3088R Phospho-Beta-Catenin (Thr41/Ser45)  磷酸化β 连环素蛋白抗体

hz-4074R phospho-Beta-catenin(Tyr86)   磷酸化β 连环素蛋白抗体

hz-2302R Catalase  过氧化氢酶抗体

hz-5271R NEK6  高度相似的细胞周期蛋白激酶NEK6抗体

hz-5272R MRG15  转录调控因子MRG15抗体

hz-5273R MLL5  髓系/淋巴混合谱系白血病蛋白5抗体

hz-1720R JUP/Cateninma γ  γ连环蛋白抗体（Catenin γ ， γ链接素）

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hz-6040R Protective protein  组织蛋白酶A抗体

hz-1500R Cathepsin B  组织蛋白酶B抗体

hz-2672R Cathepsin C  组织蛋白酶C抗体

hz-1547R Cathepsin E  组织蛋白酶E抗体

hz-1615R Cathepsin D/CTSD  组织蛋白酶D抗体