获取电话英文名称 SPCS3
中文名称 信号肽复合物亚基3抗体
别 名 DKFZp564J1864; FLJ22649; Microsomal signal peptidase 22/23 kDa subunit; Microsomal signal peptidase 23 kDa subunit; PRO3567; Signal peptidase complex subunit 3; Signal peptidase complex subunit 3 homolog (S. cerevisiae); Signal peptidase complex subunit 3 homolog; SPase 22 kDa subunit; SPase 22/23 kDa subunit; SPC22; SPC22/23; SPC3; UNQ1841; YLR066W.
信号肽复合物亚基3抗体
说 明 书 0.2ml
研究领域 细胞生物 信号转导 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Guinea Pig,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 20kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPCS3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
信号肽复合物亚基3抗体产品介绍 background:
SPCS3 (signal peptidase complex subunit 3), also known as SPC3, is a 180 amino acid single-pass type II membrane protein that localizes to both the microsome and the endoplasmic reticulum (ER) and belongs to the SPCS (signal peptidase complex subunit) family. Existing as a component of the microsomal signal peptidase complex which consists of five members, SPCS3 functions to remove signal peptides from proteins that are translated to the lumen of the ER. The gene encoding SPCS3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
Function:
A component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
Subcellular Location:
Endoplasmic reticulum and Microsome membrane;: Single-pass type II membrane protein
Database links:
Entrez Gene: 767917 Cow
Entrez Gene: 404005 Dog
Entrez Gene: 60559 Human
Entrez Gene: 76219 Mouse
Entrez Gene: 76976 Mouse
Entrez Gene: 100360464 Rat
Entrez Gene: 317409 Rat
SwissProt: Q3SZU5 Cow
SwissProt: P61008 Dog
SwissProt: P61009 Human
SwissProt: Q9D365 Mouse
SwissProt: Q568Z4 Rat
Unigene: 6322 Cow
Unigene: 3875 Dog
Unigene: 42194 Human
Unigene: 328305 Mouse
Unigene: 482965 Mouse
Unigene: 162344 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
信号肽复合物亚基3抗体
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